OSM,LIF,CTF1 receptor complex binds gp130

Stable Identifier
R-HSA-6783524
Type
Reaction
Species
Homo sapiens
Compartment
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Glycoprotein (gp)130 is the common signal transducer for LIF, OSM and CTF1 receptor complexes. gp130/OSMRbeta complex is used solely by OSM, the gp130/LIFR complex is shared by the three receptors LIF, OSM and CTF1. Binding of OSM to either the gp130/LIFR or the gp130/OSMRbeta complex triggers the activation of multiple members of the Janus kinase (JAK) family.

Literature References
PubMed ID Title Journal Year
15519241 LIF receptor signaling modulates neural stem cell renewal

Pitman, M, Emery, B, Binder, M, Wang, S, Butzkueven, H, Kilpatrick, TJ

Mol. Cell. Neurosci. 2004
2779549 Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M

Malik, N, Kallestad, JC, Gunderson, NL, Austin, SD, Neubauer, MG, Ochs, V, Marquardt, H, Zarling, JM, Shoyab, M, Wei, CM

Mol. Cell. Biol. 1989
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