STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2

Stable Identifier
R-HSA-6784006
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 phosphorylates IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STAT3 bound to IL10RA is tyrosine phosphorylated by the receptor-associated JAKs (Niemand et al. 2003, Liu et al. 2005).

Literature References
PubMed ID Title Journal Year
12626585 Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3

Niemand, C, Nimmesgern, A, Haan, S, Fischer, P, Schaper, F, Rossaint, R, Heinrich, PC, Müller-Newen, G

J. Immunol. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created