STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2

Stable Identifier
R-HSA-6784006
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 phosphorylates IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3
ReviewStatus
5/5
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STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
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STAT3 bound to IL10RA is tyrosine phosphorylated by the receptor-associated JAKs (Niemand et al. 2003, Liu et al. 2005).
Literature References
PubMed ID Title Journal Year
12626585 Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3

Schaper, F, Nimmesgern, A, Haan, S, Müller-Newen, G, Rossaint, R, Fischer, P, Niemand, C, Heinrich, PC

J. Immunol. 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane]

Physical Entity
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Bos taurus)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Canis familiaris)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Mus musculus)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Xenopus tropicalis)
Authored
Jupe, S  (2015-06-17)
Reviewed
Meldal, BH  (2016-09-05)
Created
Jupe, S  (2015-06-18)
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