STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2

Stable Identifier
R-HSA-6784006
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 phosphorylates IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3
Locations in the PathwayBrowser
Summation

STAT3 bound to IL10RA is tyrosine phosphorylated by the receptor-associated JAKs (Niemand et al. 2003, Liu et al. 2005).

Literature References
PubMed ID Title Journal Year
12626585 Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3

Niemand, C, Nimmesgern, A, Haan, S, Fischer, P, Schaper, F, Rossaint, R, Heinrich, PC, Müller-Newen, G

J. Immunol. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed