Reactome | Core 2a (MUC1) [Golgi lumen]

Core 2a (MUC1) [Golgi lumen]

Stable Identifier

R-HSA-6784286

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

Core 2 (MUC1), MUC1, MUC1_HUMAN

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External Reference Information

External Reference

UniProt:P15941 MUC1

Gene Names

MUC1, PUM

Chain

signal peptide:1-23, chain:24-1255, chain:24-1097, chain:1098-1255

Reference Genes

BioGPS Gene:4582 MUC1

COSMIC (genes):MUC1 MUC1

CTD Gene:4582 MUC1

dbSNP Gene:4582 MUC1

ENSEMBL:ENSG00000185499 MUC1

ENSEMBL_homo_sapiens_GENE:ENSG00000185499.17 MUC1

HGNC:7508 MUC1

KEGG Gene (Homo sapiens):4582 MUC1

Monarch:4582 MUC1

NCBI Gene:4582 MUC1

OMIM:158340 MUC1

UCSC:P15941 MUC1

Reference Transcript

Other Identifiers

11738366_x_at

11745158_x_at

11750536_x_at

11753640_x_at

11753651_x_at

11753678_x_at

11753692_x_at

11753818_x_at

11753973_x_at

11762687_x_at

16693976

207847_PM_s_at

207847_s_at

211695_PM_x_at

211695_x_at

213693_PM_s_at

213693_s_at

2437119

2437120

2437124

2437125

2437127

2437128

2437130

2437131

2437134

2437136

2437137

2437147

2437148

2437149

2437150

2437151

38783_at

38784_g_at

4582

700_s_at

7920642

927_s_at

A_33_P3332215

GE542853

GO:0000278

GO:0000785

GO:0000978

GO:0002039

GO:0003677

GO:0003712

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005794

GO:0005796

GO:0005886

GO:0006351

GO:0006355

GO:0006977

GO:0007155

GO:0010944

GO:0012501

GO:0016020

GO:0016324

GO:0023052

GO:0030330

GO:0031982

GO:0033629

GO:0043226

GO:0045944

GO:0051179

GO:0070062

GO:0140110

GO:1902166

Hs.89603.6.A1_3p_a_at

ILMN_1677314

ILMN_1756992

ILMN_2371911

J05582_s_at

PH_hs_0005002

TC01005848.hg

g4505282_3p_s_at

Participates

as a member of

Core 2a mucins [Golgi lumen] (Homo sapiens)

Other forms of this molecule

MUC1(24-1255) [plasma membrane]

Core 8 (MUC1) [Golgi lumen]

Core 2S (MUC1) [Golgi lumen]

Core 5 (MUC1) [Golgi lumen]

Core 4 (MUC1) [Golgi lumen]

Core 3 (MUC1) [Golgi lumen]

Core 7 (MUC1) [Golgi lumen]

extended Core 6 (MUC1) [Golgi lumen]

Core 6 (MUC1) [Golgi lumen]

MUC1(24-1255) [Golgi lumen]

Disialyl T-antigen (MUC1) [Golgi lumen]

Sialyl T-antigen (MUC1) [Golgi lumen]

Sialyl-2,3 T-antigen (MUC1) [Golgi lumen]

T-antigen (MUC1) [Golgi lumen]

Sialyl Tn antigen (MUC1) [Golgi lumen]

GalNAc-MUC1(24-1255) [Golgi lumen]

Core 2 (MUC1) [Golgi lumen]

GalNAc-MUC1(24-1255) [plasma membrane]

Inferred To

muc1 [Golgi lumen] (Xenopus tropicalis)

Muc1 [Golgi lumen] (Mus musculus)

Muc1 [Golgi lumen] (Rattus norvegicus)

cnp-2 [Golgi lumen] (Caenorhabditis elegans)

MUC1 [Golgi lumen] (Bos taurus)

MUC1 [Golgi lumen] (Canis familiaris)

MUC1 [Golgi lumen] (Sus scrofa)

Modified Residues

Name

O-(N-acetylamino)galactosyl-L-serine (N-acetyl-beta-D-glucosaminyl-(1->6)-(N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl-(1->3))-N-acetyl-alpha-D-galactosaminyl group) at unknown position

Modification

N-acetyl-beta-D-glucosaminyl-(1->6)-(N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl-(1->3))-N-acetyl-alpha-D-galactosaminyl group

PsiMod Name

O-(N-acetylamino)galactosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine.

Cross References

RefSeq

NP_001191222.1, NP_001191216.1, NP_001191221.1, NP_001018016.1, NP_001191219.1, NP_001037855.1, NP_001191215.1, NP_001191223.1, NP_001018017.1, NP_002447.4, NP_001037856.1, NP_001191218.1, NP_001191214.1, NP_001191224.1, NP_001191217.1, NP_001037857.1, NP_001191226.1, NP_001191225.1, NP_001191220.1, NP_001037858.1

OpenTargets

ENSG00000185499

GeneCards

P15941

HPA

ENSG00000185499-MUC1

Ensembl

ENSP00000357381, ENST00000337604, ENSP00000342814, ENSP00000357383, ENSP00000339690, ENST00000368392, ENST00000368390, ENST00000368393, ENSP00000357378, ENST00000368396, ENSP00000357375, ENST00000342482, ENST00000368389, ENSP00000357374, ENST00000368398, ENST00000343256, ENSP00000357377, ENSG00000185499, ENSP00000338983

PRO

P15941

Pharos - Targets

P15941

Orphanet

21979

PDB

6FZQ, 7Q4I, 8P6I, 2ACM, 7V8Q, 8AXH, 7V4W, 5T78, 7V64, 6KX1, 7V7K, 6TGG, 6FZR, 7VAC, 7VAZ, 2FO4, 1SM3, 5T6P

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.819	6
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.748	5
UniProt:P26368 U2AF2	2	5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011) U2AF2 [nucleoplasm] (R-HSA-71987)	0.471	2
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.463	4

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