p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA

Stable Identifier
R-HSA-6784324
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Synonyms
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10 dimer:2xpY-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2
Locations in the PathwayBrowser
Summation

Binding of IL-10 leads to activation of the receptor-associated Janus tyrosine kinases, JAK1 and TYK2 (Finbloom & Winestock 1995), leading to phosphorylation of IL10RA at two conserved intracellular tyrosine residues (Y446 and Y496) that serve as docking sites for STAT molecules (Ho et al. 1995, Weber-Nordt et al. 1996).

The details of receptor phosphorylation are unclear. Most descriptions of IL10 receptor tyrosine phosphorylation (Donnelly et al. 1999, Carey et al. 2012) suggest that JAK1 and TYK2 are responsible for IL10RA phosphorylation but it is not clear whether one or both kinases are responsible for phosphorylating IL10RA.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events