PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)

Stable Identifier
R-HSA-6784393
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
4-OH-L-glutamate + OA => 4-hydroxy-2-oxoglutarate (HOG) + L-Asp
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GOT2 dimer transaminates 4-OH-L-glutamate (4-OH-L-Glu) and oxaloacetate (OA) to form 4-hydroxy-2-oxoglutarate (HOG) and L-Asp. The ability of human GOT2 to catalyze this reaction has been inferred from studies of its rat homologue (Maitra & Dekker 1964).

Literature References
PubMed ID Title Journal Year
14170323 Purification of rat-liver gamma-hydroxyglutamate transaminase and its probable identity with glutamate-aspartate transaminase

Maitra, U, Dekker, EE

Biochim. Biophys. Acta 1964
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
4-hydroxyglutamate transaminase activity of GOT2 dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
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