HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

Stable Identifier
R-HSA-6784423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondrial HOGA1 aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate. The biochemical details of the enzyme are inferred from the properties of its well-studied rat homologue (Maitra & Dekker 1964). The mature protein lacks a 25-residue mitochondrial targeting sequence and forms a homotetramer (Riedel et al. 2011).

Literature References
PubMed ID Title Journal Year
14193832 Purification and properties of rat liver 2-keto-4-hydroxyglutarate aldolase

Maitra, U, Dekker, EE

J. Biol. Chem. 1964
21998747 Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria

Riedel, TJ, Johnson, LC, Knight, J, Hantgan, RR, Holmes, RP, Lowther, WT

PLoS ONE 2011
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
4-hydroxy-2-oxoglutarate aldolase activity of HOGA1 tetramer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created