CREB3L3 (1-?) translocates from cytosol to nucleoplasm

Stable Identifier
R-HSA-6784648
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The N-terminal fragment of CREB3L3 is released to the cytosol and translocates to the nucleus (Chan et al. 2010, Chin et al. 2005) to induce the transcriptional activation of different genes such as Apoa4, Apoa5, and Apoc2 apolipoproteins which exhibit stimulatory effects on lipoprotein lipase (LPL). Consistent with the essential role of LPL in TG clearance, CREB3L3-deficient mice showed hypertriglyceridemia, associated with defective production of these apolipoproteins and decreased LPL activity.

Literature References
PubMed ID Title Journal Year
20356926 N-linked glycosylation is required for optimal proteolytic activation of membrane-bound transcription factor CREB-H

Chan, CP, Mak, TY, Chin, KT, Ng, IO, Jin, DY

J. Cell. Sci. 2010
15800215 The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma

Chin, KT, Zhou, HJ, Wong, CM, Lee, JM, Chan, CP, Qiang, BQ, Yuan, JG, Ng, IO, Jin, DY

Nucleic Acids Res. 2005
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