The N-terminal fragment of CREB3L3 is released to the cytosol and translocates to the nucleus (Chan et al. 2010, Chin et al. 2005) to induce the transcriptional activation of different genes such as Apoa4, Apoa5, and Apoc2 apolipoproteins which exhibit stimulatory effects on lipoprotein lipase (LPL). Consistent with the essential role of LPL in TG clearance, CREB3L3-deficient mice showed hypertriglyceridemia, associated with defective production of these apolipoproteins and decreased LPL activity.
Chan, CP, Mak, TY, Chin, KT, Ng, IO, Jin, DY
Chin, KT, Zhou, HJ, Wong, CM, Lee, JM, Chan, CP, Qiang, BQ, Yuan, JG, Ng, IO, Jin, DY
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