Reactome | PCSK5 [extracellular region]

PCSK5 [extracellular region]

Stable Identifier

R-HSA-6784682

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser for interactor UniProt:O76003 GLRX3

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External Reference Information

External Reference

UniProt:Q92824 PCSK5

Gene Names

PCSK5, PC5, PC6

Chain

signal peptide:1-32, propeptide:33-114, chain:115-1860

Reference Genes

BioGPS Gene:5125 PCSK5

COSMIC (genes):PCSK5 PCSK5

CTD Gene:5125 PCSK5

dbSNP Gene:5125 PCSK5

ENSEMBL:ENSG00000099139 PCSK5

HGNC:8747 PCSK5

KEGG:hsa:5125 PCSK5

Monarch:5125 PCSK5

NCBI Gene:5125 PCSK5

OMIM:600488 PCSK5

UCSC:Q92824 PCSK5

Reference Transcript

Other forms of this molecule

PCSK5(115-913) [Golgi lumen]

Inferred To

F1NU61 [extracellular region] (Gallus gallus)

PCSK5 [extracellular region] (Bos taurus)

PCSK5 [extracellular region] (Canis familiaris)

Fur1 [extracellular region] (Drosophila melanogaster)

Pcsk5 [extracellular region] (Mus musculus)

Pcsk5 [extracellular region] (Rattus norvegicus)

A0A287BLN7 [extracellular region] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2385

OpenTargets

ENSG00000099139

ENSEMBL

ENSP00000446280, ENST00000376752, ENST00000545128, ENSP00000365943, ENSG00000099139

ZINC - Substances

PCSK5_HUMAN

HPA

ENSG00000099139-PCSK5

GeneCards

PCSK5

ZINC target

Q92824

PRO

Q92824

Pharos - Targets

Q92824

ZINC - Predictions - Purchasable

PCSK5_HUMAN

GlyGen

Q92824

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:Q5T5A8 LCE3C	1	LCE3C [cytosol] (R-HSA-6814279)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q7Z417 NUFP2			0.556	3
UniProt:Q9BQ66 KR412			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q03405 PLAUR	7	GPI-PLAUR [specific granule membrane] (R-HSA-6806143) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR [endoplasmic reticulum membrane] (R-HSA-162703)	0.527	2
UniProt:Q9Y2Y8 PRG3	3	PRG3 [specific granule lumen] (R-HSA-6799555) PRG3 [extracellular region] (R-HSA-6806299) PRG3 [tertiary granule lumen] (R-HSA-6800905)	0.527	2
UniProt:O15496 PLA2G10	1	PLA2G10 [extracellular region] (R-HSA-1498793)	0.527	2
UniProt:Q9Y5Q6 INSL5	2	INSL5(115-135) [extracellular region] (R-HSA-444867) INSL5(23-48) [extracellular region] (R-HSA-444855)	0.527	2
UniProt:P09093 CEL3A			0.527	2
UniProt:Q96T91 GPHA2	1	GPHA2 [extracellular region] (R-HSA-8942422)	0.527	2
UniProt:P13727 PRG2	2	PRG2 [extracellular region] (R-HSA-6806492) PRG2 [ficolin-1-rich granule lumen] (R-HSA-6801280)	0.527	3

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