p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3

Stable Identifier
R-HSA-6784791
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once phosphorylated, STAT3 dissociates from the receptor, dimerizes with other STAT3 molecules, and translocates to the nucleus where it binds with high affinity to STAT-binding elements (SBEs) in the promoters of IL-10-inducible genes (Donnelly et al. 1999).

Literature References
PubMed ID Title Journal Year
10433356 The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes J. Interferon Cytokine Res. 1999
Participants
Participant Of
Orthologous Events