Reactome | AP2A2(1-939) [endolysosome membrane]

AP2A2(1-939) [endolysosome membrane]

Stable Identifier

R-HSA-6784819

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endolysosome membrane

Synonyms

Adaptor protein AP2A2

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - MHC class II antigen presentation (Homo sapiens)
    - Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
    - Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
      - Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A2(1-939) [endolysosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94973 AP2A2

Gene Names

AP2A2, ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899

Chain

chain:1-939

Reference Genes

ENSEMBL:ENSG00000183020 AP2A2

Participates

as a member of

Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)

Other forms of this molecule

AP2A2(1-939) [secretory granule membrane]

AP2A2(1-939) [ficolin-1-rich granule membrane]

AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]

AP2A2(1-939) [cytosol]

AP2A2(1-939) [plasma membrane]

Inferred To

apl3 [endolysosome membrane] (Schizosaccharomyces pombe)

AP-2alpha [endolysosome membrane] (Drosophila melanogaster)

ap2a1-2 [endolysosome membrane] (Dictyostelium discoideum)

APL3 [endolysosome membrane] (Saccharomyces cerevisiae)

AP2A2(1-939) [endolysosome membrane] (Bos taurus)

AP2A2(1-939) [endolysosome membrane] (Caenorhabditis elegans)

AP2A2(1-939) [endolysosome membrane] (Canis familiaris)

AP2A2(1-939) [endolysosome membrane] (Gallus gallus)

AP2A2(1-939) [endolysosome membrane] (Mus musculus)

AP2A2(1-939) [endolysosome membrane] (Rattus norvegicus)

AP2A2(1-939) [endolysosome membrane] (Sus scrofa)

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.643	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.643	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.569	4
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.527	2
UniProt:P98078	3	Dab2 [cytosol] (R-MMU-8862456) Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [plasma membrane] (R-MMU-2980808)	0.499	2

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