IL10 enhances activated monocyte expression of the natural antagonists interleukin-1 receptor antagonist (IL1RN), TNFRSF1A (soluble p55 TNFR) and TNFRSF1B (p75 TNFR) (Cassatella et al 1994, Hart et al. 1996, Joyce & Steer 1996, Linderholm et al. 1996, Dickensheets et al. 1997).
IL10 enhances production of tissue inhibitor of metalloproteinases (TIMP1) and hyaluronectin, which bind and inhibit the angiogenic- and migration-promoting activities of hyaluronic acid (Mertz et al. 1994, Lacraz et al. 1995, Stearns et al. 1999, Girard et al. 1999).