FA core complex assembles at DNA interstrand crosslinks (ICLs)

Stable Identifier
R-HSA-6785126
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In addition to FANCM, FAAP24, APITD1 (MHF1) and STRA13 (MHF2), the FA core complex also includes FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FAAP20 and FAAP100 (Singh et al. 2010, Yan et al. 2010, Leung et al. 2012). While FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCL, and probably FAAP20 and FAAP100, can assemble a complex in the nucleoplasm, they are unable to load onto DNA in the absence of FANCM and FAAP24 (Kim et al. 2008, Yan et al. 2010, Leung et al. 2012).

Literature References
PubMed ID Title Journal Year
22396592 Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair

Leung, JW, Wang, Y, Fong, KW, Huen, MS, Li, L, Chen, J

Proc. Natl. Acad. Sci. U.S.A. 2012
18174376 Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24

Kim, JM, Kee, Y, Gurtan, A, D'Andrea, AD

Blood 2008
20347429 MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM

Singh, TR, Saro, D, Ali, AM, Zheng, XF, Du, CH, Killen, MW, Sachpatzidis, A, Wahengbam, K, Pierce, AJ, Xiong, Y, Sung, P, Meetei, AR

Mol. Cell 2010
20347428 A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability

Yan, Z, Delannoy, M, Ling, C, Daee, D, Osman, F, Muniandy, PA, Shen, X, Oostra, AB, Du, H, Steltenpool, J, Lin, T, Schuster, B, D├ęcaillet, C, Stasiak, A, Stasiak, AZ, Stone, S, Hoatlin, ME, Schindler, D, Woodcock, CL, Joenje, H, Sen, R, de Winter, JP, Li, L, Seidman, MM, Whitby, MC, Myung, K, Constantinou, A, Wang, W

Mol. Cell 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created