NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)

Stable Identifier
R-HSA-6785409
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NSUN2 transfers methyl groups from S-adenosylmethionine to the 5 positions of cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Squires et al. 2012, Khoddami et al. 2013).

Literature References
PubMed ID Title Journal Year
22344696 Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

Squires, JE, Patel, HR, Nousch, M, Sibbritt, T, Humphreys, DT, Parker, BJ, Suter, CM, Preiss, T

Nucleic Acids Res. 2012
23604283 Identification of direct targets and modified bases of RNA cytosine methyltransferases

Khoddami, V, Cairns, BR

Nat. Biotechnol. 2013
Participants
Participant Of
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Catalyst Activity
Catalyst Activity
Title
tRNA (cytosine-5-)-methyltransferase activity of NSUN2 [nucleoplasm]
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Activity
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