NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)

Stable Identifier
R-HSA-6785438
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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NSUN2 transfers methyl groups from S-adenosylmethionine to the 5 positions of cytidine-40, cytidine-48, cytidine-49, and cytidine-50 of tRNA(Gly)(GCC) (Auxilien et al. 2012, Khoddami and Cairns 2013).
Literature References
PubMed ID Title Journal Year
22995836 The human tRNA m (5) C methyltransferase Misu is multisite-specific

Auxilien, S, Golinelli-Pimpaneau, B, Guérineau, V, Szweykowska-Kulińska, Z

RNA Biol 2012
23604283 Identification of direct targets and modified bases of RNA cytosine methyltransferases

Cairns, BR, Khoddami, V

Nat. Biotechnol. 2013
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Event Information
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Catalyst Activity

tRNA (cytosine-5-)-methyltransferase activity of NSUN2 [nucleoplasm]

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