Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
FAN1 [nucleoplasm]
Stable Identifier
R-HSA-6785736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Fanconi-associated nuclease 1, KIAA1018, MTMR15, FANCD2/FANCI-associated nuclease 1
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
FAN1 [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
FAN1 dimer [nucleoplasm] (Homo sapiens)
FAN1 [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
FAN1 [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
FAN1 dimer [nucleoplasm] (Homo sapiens)
FAN1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2M0 FAN1
Gene Names
FAN1, KIAA1018, MTMR15
Chain
chain:1-1017
Reference Genes
BioGPS Gene:22909 FAN1
COSMIC (genes):FAN1 FAN1
CTD Gene:22909 FAN1
dbSNP Gene:22909 FAN1
ENSEMBL:ENSG00000198690 FAN1
HGNC:29170 FAN1
KEGG:hsa:22909 FAN1
Monarch:22909 FAN1
NCBI Gene:22909 FAN1
OMIM:613534 FAN1
UCSC:Q9Y2M0 FAN1
Reference Transcript
RefSeq:XM_005254232.4 FAN1
RefSeq:NM_001146094.1 FAN1
RefSeq:NM_001146095.1 FAN1
RefSeq:NM_001146096.1 FAN1
RefSeq:XM_005254235.3 FAN1
RefSeq:NM_014967.4 FAN1
RefSeq:XM_005254234.4 FAN1
Other Identifiers
11744666_at
11756510_a_at
16798842
203678_PM_at
203678_at
22909
232016_PM_at
232016_at
239289_PM_x_at
239289_x_at
3586835
3586836
3586837
3586838
3586839
3586840
3586841
3586842
3586843
3586845
3586846
3586848
3586849
3586850
3586851
3586852
3586853
3586854
3586855
3586856
3586857
3586862
3586863
3586864
3586865
3586866
3586867
3586868
3586869
3586870
3586871
3586872
3586874
3586876
36458_at
7982309
83006_at
91115_at
A_14_P119127
A_14_P131644
A_23_P377888
GE53657
GO:0000287
GO:0000724
GO:0003676
GO:0003677
GO:0003824
GO:0004518
GO:0004519
GO:0004527
GO:0004528
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006281
GO:0006289
GO:0006310
GO:0008409
GO:0016787
GO:0016788
GO:0017108
GO:0036297
GO:0043226
GO:0045171
GO:0046872
GO:0060090
GO:0070336
GO:0140036
GO:0140097
HMNXSV003013449
HMNXSV003022536
Hs.143981.0.A1_3p_at
Hs.147317.0.S1_3p_at
ILMN_1778734
ILMN_2152178
PH_hs_0000557
TC15000194.hg
g7662449_3p_at
p5479
Participates
as an output of
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
as a component of
FAN1 dimer [nucleoplasm] (Homo sapiens)
as an input of
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
Inferred To
Fan1 [nucleoplasm]
(Rattus norvegicus)
FAN1 [nucleoplasm]
(Bos taurus)
FAN1 [nucleoplasm]
(Canis familiaris)
FAN1 [nucleoplasm]
(Gallus gallus)
FAN1 [nucleoplasm]
(Mus musculus)
FAN1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
XP_005254291.1
,
XP_005254292.1
,
NP_001139566.1
,
NP_055782.3
,
NP_001139567.1
,
NP_001139568.1
,
XP_005254289.1
OpenTargets
ENSG00000198690
ENSEMBL
ENSP00000454544
,
ENSP00000455983
,
ENST00000561607
,
ENST00000656435
,
ENST00000658773
,
ENST00000670849
,
ENST00000621063
,
ENSP00000354497
,
ENSP00000454223
,
ENSP00000499638
,
ENSP00000499703
,
ENST00000561594
,
ENST00000362065
,
ENST00000565466
,
ENST00000657391
,
ENSP00000499742
,
ENSP00000499534
,
ENSP00000484956
HPA
ENSG00000198690-FAN1
PRO
Q9Y2M0
Pharos - Targets
Q9Y2M0
Orphanet
FAN1
GlyGen
Q9Y2M0
PDB
4RID
,
4REA
,
4REB
,
4RIA
,
4REC
,
4RIB
,
4RI8
,
4RI9
,
4RY3
,
4RIC
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40692 MLH1
3
MLH1 [nucleoplasm]
(R-HSA-912495)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
0.527
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text