Reactome | Expression of IL4, IL13-upregulated extracellular proteins

Expression of IL4, IL13-upregulated extracellular proteins

Stable Identifier

R-HSA-6785895

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

extracellular region, nucleoplasm

Locations in the PathwayBrowser

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Summation

In human peripheral blood monocytes IL4 and IL13 significantly upregulate the levels of several extracellular proteins involved in inflammatory resolution including fibronectin (FN1), coagulation factor XIII (FXIII), annexin 1 (ANXA1), collagen type 1 alpha 2 (COL1A2), laminin alpha-5 (LAMA5) and C-C motif chemokine 22 (CCL22) (Chaitidis et al. 2005, Jinnin et al. 2004, Yakubenko et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21252155	?M��?? integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formation	Circ. Res.	2011
15869882	Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13	Cytokine	2005

Participants

Input

IL4,IL13-upregulated extracellular genes [nucleoplasm] (Homo sapiens)

Output

IL4,IL13-upregulated extracellular proteins [extracellular region] (Homo sapiens)

Participant Of

hasEvent

Interleukin-4 and Interleukin-13 signaling

This entity is regulated by

Positive Regulation

Positive regulation by 'IL4, IL13 [extracellular region]'

Authored

Jupe, Steve, 2015-07-01

Reviewed

Leibovich, Samuel, 2016-09-02