Expression of IL4, IL13-upregulated extracellular proteins

Stable Identifier
R-HSA-6785895
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
extracellular region, nucleoplasm
Locations in the PathwayBrowser
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Summation

In human peripheral blood monocytes IL4 and IL13 significantly upregulate the levels of several extracellular proteins involved in inflammatory resolution including fibronectin (FN1), coagulation factor XIII (FXIII), annexin 1 (ANXA1), collagen type 1 alpha 2 (COL1A2), laminin alpha-5 (LAMA5) and C-C motif chemokine 22 (CCL22) (Chaitidis et al. 2005, Jinnin et al. 2004, Yakubenko et al. 2011).

Literature References
PubMed ID Title Journal Year
21252155 ?Mßâ?? integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formation

Yakubenko, VP, Bhattacharjee, A, Pluskota, E, Cathcart, MK

Circ. Res. 2011
15869882 Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13

Chaitidis, P, O'Donnell, V, Kuban, RJ, Bermudez-Fajardo, A, Ungethuem, U, Kühn, H

Cytokine 2005
Participants
Input
Output
Participant Of
hasEvent
This entity is regulated by
Positive Regulation
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)