Reactome | CHST8 [Golgi membrane]

CHST8 [Golgi membrane]

Stable Identifier

R-HSA-6786024

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Carbohydrate sulfotransferase 8 ecNumber2.8.2.-/ecNumber, CHST8_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Homo sapiens)
        
        CHST8 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H2A9 CHST8

Gene Names

CHST8

Chain

chain:1-424

Reference Genes

BioGPS Gene:64377 CHST8

COSMIC (genes):CHST8 CHST8

CTD Gene:64377 CHST8

dbSNP Gene:64377 CHST8

ENSEMBL:ENSG00000124302 CHST8

ENSEMBL_homo_sapiens_GENE:ENSG00000124302.13 CHST8

HGNC:15993 CHST8

KEGG Gene (Homo sapiens):64377 CHST8

Monarch:64377 CHST8

NCBI Gene:64377 CHST8

OMIM:610190 CHST8

UCSC:Q9H2A9 CHST8

Reference Transcript

Other Identifiers

11730512_a_at

16860655

221065_PM_s_at

221065_s_at

3829399

3829400

3829402

3829405

3829406

3829407

3829408

3829410

3829411

3829450

3829453

3829454

3829455

3829456

64377

8027574

A_23_P90275

GE61722

GO:0000139

GO:0001537

GO:0003824

GO:0005515

GO:0005794

GO:0005975

GO:0006790

GO:0007417

GO:0008146

GO:0016020

GO:0016051

GO:0016740

GO:0030166

GO:0042446

GO:0043226

GO:0048856

GO:1901135

HMNXSV003044329

ILMN_1795845

PH_hs_0009988

TC19000438.hg

g11968014_3p_a_at

Inferred To

CHST8 [Golgi membrane] (Bos taurus)

CHST8 [Golgi membrane] (Mus musculus)

CHST8 [Golgi membrane] (Sus scrofa)

Cross References

RefSeq

NP_001121367.1, XP_011525526.1, NP_071912.2, XP_016882632.1, NP_001121368.1, XP_011525524.1

OpenTargets

ENSG00000124302

HPA

ENSG00000124302-CHST8

GeneCards

Q9H2A9

Ensembl

ENST00000434302, ENST00000438847, ENSG00000124302, ENSP00000499084, ENSP00000392604, ENST00000262622, ENSP00000262622, ENSP00000393879, ENST00000650847

PRO

Q9H2A9

Pharos - Targets

Q9H2A9

Orphanet

22349

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28329-3 P283293			0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q92791 SC65			0.527	2
UniProt:Q15363 TMED2	5	TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-1911531) TMED2 [endoplasmic reticulum membrane] (R-HSA-5689480) TMED2 [ER to Golgi transport vesicle membrane] (R-HSA-5689847) TMED2 [transport vesicle] (R-HSA-6808806) TMED2 [Golgi membrane] (R-HSA-6808804)	0.527	3
UniProt:Q99999 GAL3ST1	1	GAL3ST1 [Golgi membrane] (R-HSA-1631586)	0.527	2
UniProt:Q92520 FAM3C	2	FAM3C [extracellular region] (R-HSA-8848922) FAM3C [platelet dense granule lumen] (R-HSA-8848884)	0.527	2
UniProt:Q8IXK2 GALNT12	6	GALNT12 Y395* [Golgi membrane] (R-HSA-5138160) GALNT12 M1I [Golgi membrane] (R-HSA-5138151) GALNT12 Y396C [Golgi membrane] (R-HSA-5138168) GALNT12 D303N [Golgi membrane] (R-HSA-5138141) GALNT12 T491M [Golgi membrane] (R-HSA-5138143) GALNT12 [Golgi membrane] (R-HSA-913627)	0.527	3
UniProt:Q9Y6H1 CHCHD2	2	2xHC-CHCHD2 [mitochondrial intermembrane space] (R-HSA-6800100) CHCHD2 [mitochondrial intermembrane space] (R-HSA-1307777)	0.527	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.527	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.527	3
UniProt:Q8NCR0 B3GALNT2	1	B3GALNT2 [endoplasmic reticulum membrane] (R-HSA-8878916)	0.527	3
UniProt:Q8N8L6 ARL10			0.527	2
UniProt:Q9BVK6 TMED9	4	TMED9 [endoplasmic reticulum membrane] (R-HSA-6811016) TMED9 [Golgi membrane] (R-HSA-6808813) TMED9 [transport vesicle] (R-HSA-6808878) TMED9 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807777)	0.527	3
UniProt:P56182 RRP1	1	RRP1 [nucleoplasm] (R-HSA-6792441)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	3
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	3

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