IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated

Stable Identifier
R-HSA-6786050
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Interleukin-4 receptor alpha subunit (IL4R) and Interleukin-13 receptor subunit alpha 1 (IL13RA1) are phosphorylated on tyrosines in response to Interleukin-13 (IL13) in human blood monocytes (Roy et al. 2002, Bhattacharjee et al. 2013). The associated Janus-kinase (JAK) family kinases JAK2 and TYK2 are also phosphorylated (Roy & Cathcart 1998, Bhattacharjee et al. 2013). Although JAK1 binds to IL4R in response to IL13, it does not appear to be phosphorylated in response to IL13 (Roy & Cathcart 1998, Bhattacharjee et al. 2013).

Literature References
PubMed ID Title Journal Year
9822675 Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes

Roy, B, Cathcart, MK

J. Biol. Chem. 1998
12223527 IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats

Roy, B, Bhattacharjee, A, Xu, B, Ford, D, Maizel, AL, Cathcart, MK

J. Leukoc. Biol. 2002
23124025 IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

Bhattacharjee, A, Shukla, M, Yakubenko, VP, Mulya, A, Kundu, S, Cathcart, MK

Free Radic. Biol. Med. 2013
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