Reactome | IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated

IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated

Stable Identifier

R-HSA-6786050

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated

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Interleukin-4 receptor alpha subunit (IL4R) and Interleukin-13 receptor subunit alpha 1 (IL13RA1) are phosphorylated on tyrosines in response to Interleukin-13 (IL13) in human blood monocytes (Roy et al. 2002, Bhattacharjee et al. 2013). The associated Janus-kinase (JAK) family kinases JAK2 and TYK2 are also phosphorylated (Roy & Cathcart 1998, Bhattacharjee et al. 2013). Although JAK1 binds to IL4R in response to IL13, it does not appear to be phosphorylated in response to IL13 (Roy & Cathcart 1998, Bhattacharjee et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
12223527	IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats Roy, B, Ford, D, Maizel, AL, Cathcart, MK, Bhattacharjee, A, Xu, B	J. Leukoc. Biol.	2002
9822675	Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes Roy, B, Cathcart, MK	J. Biol. Chem.	1998
23124025	IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages Yakubenko, VP, Mulya, A, Cathcart, MK, Kundu, S, Bhattacharjee, A, Shukla, M	Free Radic. Biol. Med.	2013