Reactome | p-Y-IL4R [plasma membrane]

p-Y-IL4R [plasma membrane]

Stable Identifier

R-HSA-6786087

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IL4RA, Interleukin-4 receptor alpha chain, IL4RA_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
      - IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
      - JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
      - STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
      - STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
      - STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
      - p-Y-STATs dissociate (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL4R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24394 IL4R

Gene Names

IL4R, IL4RA, 582J2.1

Chain

signal peptide:1-25, chain:26-825, chain:26-

Reference Genes

BioGPS Gene:3566 IL4R

COSMIC (genes):IL4R IL4R

CTD Gene:3566 IL4R

dbSNP Gene:3566 IL4R

ENSEMBL:ENSG00000077238 IL4R

ENSEMBL_homo_sapiens_GENE:ENSG00000077238.14 IL4R

HGNC:6015 IL4R

KEGG Gene (Homo sapiens):3566 IL4R

Monarch:3566 IL4R

NCBI Gene:3566 IL4R

OMIM:147781 IL4R

UCSC:P24394 IL4R

Reference Transcript

Other Identifiers

11718073_at

11718074_a_at

11718075_at

11742511_a_at

11748724_a_at

16817254

203233_PM_at

203233_at

3566

3654176

3654183

3654186

3654187

3654189

3654190

3654195

3654200

3654201

3654202

3654206

3654207

3654210

3654211

3654212

3654213

3654214

3654215

3654216

3654217

404_at

7994280

A_23_P129556

A_33_P3349045

A_33_P3395947

GE53990

GO:0002376

GO:0002532

GO:0002639

GO:0004896

GO:0004913

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005815

GO:0005856

GO:0005886

GO:0006954

GO:0006955

GO:0007155

GO:0007165

GO:0009897

GO:0016020

GO:0016064

GO:0016192

GO:0019221

GO:0023052

GO:0030154

GO:0032722

GO:0034451

GO:0035771

GO:0042832

GO:0043032

GO:0043226

GO:0043235

GO:0043306

GO:0045063

GO:0045064

GO:0045626

GO:0045630

GO:0048856

GO:0060089

GO:0098542

GO:0120162

GO:1901741

HMNXSV003009200

HMNXSV003012450

ILMN_1652185

PH_hs_0004340

TC16000293.hg

X52425_at

g4557668_3p_at

Participates

as a component of

Other forms of this molecule

IL4R [plasma membrane]

Inferred To

phospho-p-Y-IL4R [plasma membrane] (Gallus gallus)

phospho-Il4r [plasma membrane] (Mus musculus)

phospho-Il4r [plasma membrane] (Rattus norvegicus)

phospho-IL4R [plasma membrane] (Bos taurus)

phospho-IL4R [plasma membrane] (Canis familiaris)

phospho-IL4R [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011544129.1, XP_011544128.1, XP_011544127.1, NP_001244336.1, NP_000409.1, NP_001244335.1

Guide to Pharmacology - Targets

1697

OpenTargets

ENSG00000077238

HPA

ENSG00000077238-IL4R

GeneCards

P24394

Ensembl

ENSP00000379111, ENST00000170630, ENST00000543915, ENSP00000170630, ENSP00000441667, ENST00000395762, ENSG00000077238

PRO

P24394

Pharos - Targets

P24394

PDB

3BPO, 3BPL, 3BPN, 1IRS, 5E4E, 6OEL, 1IAR, 6WGL

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05112 IL4	1	IL4 [extracellular region] (R-HSA-447110)	0.811	7
UniProt:P31785 IL2RG	4	IL2RG [endosome] (R-HSA-8983165) p-Y-IL2RG [cytosol] (R-HSA-9009721) p-Y-IL2RG [plasma membrane] (R-HSA-6786103) IL2RG [plasma membrane] (R-HSA-449139)	0.667	5
UniProt:P42226 STAT6	6	p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407-STAT6 [cytosol] (R-HSA-3249369) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-Y641-STAT6 [cytosol] (R-HSA-6786109)	0.643	4
UniProt:P78552 IL13RA1	2	IL13RA1 [plasma membrane] (R-HSA-449671) p-Y-IL13RA1 [plasma membrane] (R-HSA-6786750)	0.558	4
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.527	2

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