IL4:IL4R:JAK2 binds IL2RG:JAK3

Stable Identifier
R-HSA-6786092
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin 2 receptor gamma subunit (IL2RG), with constitutively-associated Janus kinase 3 (JAK3), binds the IL4:IL4R:JAK2 complex, interacting with IL4 and IL4R to form the ligand-bound type I IL4 receptor complex, IL4R1 (LaPorte et al. 2008).

Literature References
PubMed ID Title Journal Year
18243101 Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

Laporte, SL, Juo, ZS, Vaclavikova, J, Colf, LA, Qi, X, Heller, NM, Keegan, AD, Garcia, KC

Cell 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!