IL13 binds IL13RA:TYK2

Stable Identifier
R-HSA-6786118
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The type II Interleukin-13 (IL13) receptor complex (IL13R2) forms with IL13 binding to Interleukin-13 receptor alpha subunit 1 (IL13RA1), which is constitutively bound to Non-receptor tyrosine kinase 2 (TYK2), followed by recruitment of Interleukin-4 receptor subunit alpha (IL4R), which is associated with Janus kinase 2 (JAK2) (Wang et al. 2009). IL13RA1 binds IL13 with low affinity (Kd = 2-10 nmol/L) (Miloux et al. 1997).

Literature References
PubMed ID Title Journal Year
9013879 Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex

Miloux, B, Laurent, P, Bonnin, O, Lupker, J, Caput, D, Vita, N, Ferrara, P

FEBS Lett 1997
Participants
Participant Of
Orthologous Events
Authored
Reviewed