POLN binds ICL-DNA

Stable Identifier
R-HSA-6786155
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

An error-prone DNA polymerase nu (POLN) is recruited to the interstrand crosslink (ICL) repair site through interaction with monoubiquitinated FANCD2 and probably the PCNA subunit of the stalled replication complex (Moldovan et al. 2010).

Literature References
PubMed ID Title Journal Year
19995904 DNA polymerase POLN participates in cross-link repair and homologous recombination

Moldovan, GL, Madhavan, MV, Mirchandani, KD, McCaffrey, RM, Vinciguerra, P, D'Andrea, AD

Mol. Cell. Biol. 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed