Translesion synthesis across unhooked ICL by POLN

Stable Identifier
Reaction [omitted]
Homo sapiens
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The error-prone DNA polymerase nu (POLN) performs translesion DNA synthesis using the DNA strand with unhooked interstrand crosslink (ICL) as a template, thereby bypassing the unhooked ICL (Moldovan et al. 2010, Yamanaka et al. 2010). The DNA strand with unhooked ICL is subsequently repaired via nucleotide excision repair (NER), while the double strand break (DSB) generated by incision of the stalled replication fork during the unhooking step is repaired via homologous recombination repair (HRR) (reviewed by Kottemann and Smogorzewska 2013, Deans and West 2011).
Literature References
PubMed ID Title Journal Year
19995904 DNA polymerase POLN participates in cross-link repair and homologous recombination

Moldovan, GL, Madhavan, MV, Vinciguerra, P, McCaffrey, RM, Mirchandani, KD, D'Andrea, AD

Mol. Cell. Biol. 2010
20102227 Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links

Rizzo, CJ, Kozekov, ID, Lloyd, RS, Wood, RD, Takata, K, Kolbanovskiy, A, Minko, IG, Yamanaka, K

Chem. Res. Toxicol. 2010
21701511 DNA interstrand crosslink repair and cancer

West, SC, Deans, AJ

Nat. Rev. Cancer 2011
23325218 Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

Kottemann, MC, Smogorzewska, A

Nature 2013
Catalyst Activity

DNA-directed DNA polymerase activity of MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm]

Orthologous Events
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