Reactome | FANCD2 deubiquitination by USP1:WDR48

FANCD2 deubiquitination by USP1:WDR48

Stable Identifier

R-HSA-6786171

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The FA pathway is negatively regulated through the USP1:WDR48-mediated deubiquitination of FANCD2 (Nijman et al. 2005). WDR48 (UAF1) forms a complex with and activates USP1 (Cohn et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
18082604	A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway Cohn, MA, Gygi, SP, Huang, TT, Yang, K, D'Andrea, AD, Haas, W, Kowal, P	Mol Cell	2007