CMBL hydrolyses OM to OLMS

Stable Identifier
R-HSA-6786190
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Carboxymethylenebutenolidase homolog (CMBL) is a cytosolic hydrolase enzyme present in liver and intestine. It is able to hydrolyse medoxomil-type pro-drugs to their pharmacologically active metabolites. Olmesartan medoxomil (OM) is an angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. It is hydrolysed by CMBL to its active metabolite olmesartan (OLMS) (Ishizuka et al 2010). True physiological substrates of CMBL remain unknown.

Literature References
PubMed ID Title Journal Year
20177059 Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine

Ishizuka, T, Fujimori, I, Kato, M, Noji-Sakikawa, C, Saito, M, Yoshigae, Y, Kubota, K, Kurihara, A, Izumi, T, Ikeda, T, Okazaki, O

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydrolase activity of CMBL [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created