CARNS1 transforms ATP, L-His, b-Ala to CARN

Stable Identifier
R-HSA-6786245
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine) are abundant dipeptides in skeletal muscle and brain of most vertebrates. Carnosine synthase 1 (CARNS1) transforms ATP, L-histidine (L-His) and beta-alanine (b-Ala) to carnosine (CARN) with much greater efficiency than synthesis of homocarnosine (Drozak et al. 2010).

Literature References
PubMed ID Title Journal Year
20097752 Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)

Drozak, J, Veiga-da-Cunha, M, Vertommen, D, Stroobant, V, Van Schaftingen, E

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
carnosine synthase activity of CARNS1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created