Reactome | GTPBP3 [mitochondrial matrix]

GTPBP3 [mitochondrial matrix]

Stable Identifier

R-HSA-6787414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

tRNA modification GTPase GTPBP3, mitochondrial, GTPB3_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q13352 ITGB3BP

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External Reference Information

External Reference

UniProt:Q969Y2 GTPBP3

Gene Names

GTPBP3, MTGP1

Chain

transit peptide:1-81, chain:82-492

Reference Genes

BioGPS Gene:84705 GTPBP3

COSMIC (genes):GTPBP3 GTPBP3

CTD Gene:84705 GTPBP3

dbSNP Gene:84705 GTPBP3

ENSEMBL:ENSG00000130299 GTPBP3

HGNC:14880 GTPBP3

Monarch:84705 GTPBP3

NCBI Gene:84705 GTPBP3

OMIM:608536 GTPBP3

UCSC:Q969Y2 GTPBP3

Reference Transcript

Other Identifiers

11724991_a_at

11724992_x_at

11733958_a_at

11733959_x_at

11753176_a_at

1555062_PM_s_at

1555062_s_at

16859493

213835_PM_x_at

213835_x_at

3824227

3824228

3824229

3824230

3824231

3824232

3824233

3824234

3824235

3824236

3824237

3824238

3824239

3824240

3824241

3824242

3824243

3824244

3824245

3824246

3824247

3824248

3824249

3824250

3824251

3824252

3824253

3824254

3824255

3824256

3824257

3824258

8026735

84705

A_14_P139182

A_23_P28068

GE83456

GO:0002098

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005739

GO:0006399

GO:0006400

GO:0008033

GO:0016787

GO:0030488

GO:0043226

HMNXSV003043297

Hs.246112.3.S1_3p_at

Hs2.334885.3.S1_3p_s_at

ILMN_1686587

ILMN_1748894

ILMN_1777156

PH_hs_0016491

PH_hs_0040701

TC19000333.hg

p26068

This entity regulates

Positively

GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA (Homo sapiens)

Cross References

OpenTargets

ENSG00000130299

ENSEMBL

ENSP00000473150, ENST00000361619, ENSP00000351644, ENST00000324894, ENST00000358792, ENSP00000313818, ENSP00000354598, ENST00000600625

HPA

ENSG00000130299-GTPBP3

PRO

Q969Y2

Pharos - Targets

Q969Y2

GlyGen

Q969Y2

Orphanet

GTPBP3

HMDB Protein

HMDBP08440

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13352 ITGB3BP	2	ITGB3BP [nucleoplasm] (R-HSA-606325) ITGB3BP [cytosol] (R-HSA-3006405)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:Q53GL6 Q53GL6			0.556	5
UniProt:Q9BV29 CCD32			0.556	3
UniProt:Q8TF47 ZFP90	1	ZFP90 [nucleoplasm] (R-HSA-974988)	0.556	3
UniProt:Q99081-3 TCF12			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:O95994 AGR2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q6DHY5 TBC3G			0.556	3
UniProt:Q15293 RCN1	2	p-RCN1 [endoplasmic reticulum lumen] (R-HSA-8956989) RCN1 [endoplasmic reticulum lumen] (R-HSA-8956758)	0.556	3
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.556	3
UniProt:Q9Y223 GNE	9	GNE V572L [cytosol] (R-HSA-4088323) GNE M712T [cytosol] (R-HSA-4088386) GNE R263L [cytosol] (R-HSA-4088402) GNE R266W [cytosol] (R-HSA-4088372) GNE R266Q [cytosol] (R-HSA-4088390) GNE A631V [cytosol] (R-HSA-4088376) GNE M171V [cytosol] (R-HSA-4088351) GNE C303V [cytosol] (R-HSA-4088366) GNE [cytosol] (R-HSA-3781927)	0.556	3
UniProt:Q9NR21-1 PARP11			0.556	7
UniProt:Q96D03 DDT4L			0.556	5
UniProt:P17858 PFKL	4	PFKL [ficolin-1-rich granule lumen] (R-HSA-6801030) PFKL [extracellular region] (R-HSA-6806471) PFKL [secretory granule lumen] (R-HSA-6800876) PFKL [cytosol] (R-HSA-70459)	0.556	3
UniProt:P20807-4 CAPN3			0.556	3
UniProt:Q8WUT1 Q8WUT1			0.556	3
UniProt:Q9UC07-2 ZNF69			0.556	3
UniProt:Q6NYC8 PPR18			0.556	3
UniProt:Q8N7W2-2 BEND7			0.556	3
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.553	2

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