TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser)

Stable Identifier
R-HSA-6787567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TRIT1 transfers a dimethylallyl group (isopentenyl group) from dimethylallyl diphosphate to the N6 position of adenosine-37 in mitochondrial tRNA(Ser,UCN), yielding N6-dimethylallyladenosine-37 (N6-isopentenyladenosine-37) (Lamichhane et al. 2013, Yarham et al. 2014). TRIT1 modifies both cytosolic and mitochondrial tRNAs and a mutation in TRIT1 causes defects in mitochondrial protein synthesis and respiration (Yarham et al. 2014).

Literature References
PubMed ID Title Journal Year
24126054 Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor

Lamichhane, TN, Mattijssen, S, Maraia, RJ

Mol. Cell. Biol. 2013
24901367 Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA

Yarham, JW, Lamichhane, TN, Pyle, A, Mattijssen, S, Baruffini, E, Bruni, F, Donnini, C, Vassilev, A, He, L, Blakely, EL, Griffin, H, Santibanez-Koref, M, Bindoff, LA, Ferrero, I, Chinnery, PF, McFarland, R, Maraia, RJ, Taylor, RW

PLoS Genet. 2014
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Event Information
Catalyst Activity
Catalyst Activity
Title
tRNA dimethylallyltransferase activity of TRIT1 [mitochondrial matrix]
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Created