HDHD1:Mg2+ dephosphorylates PURIDP

Stable Identifier
R-HSA-6788295
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Pseudouridine 5'-phosphate (PURIDP) is a potential intermediate in RNA degradation. Pseudouridine 5'-phosphatase (HDHD1) is a Mg2+-dependent enzyme present in erythrocytes that can dephosphorylate PURIDP to pseudouridine (PURID), the fifth-most abundant nucleoside in RNA. PURID is not metabolised in mammals but excreted intact in urine (Preumont et al. 2010).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydrolase activity of HDHD1:Mg2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea