The complex of ATR and ATRIP is recruited to ICL-DNA

Stable Identifier
R-HSA-6788385
Type
Reaction [binding]
Species
Homo sapiens
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The complex of ATR and ATRIP (ATR:ATRIP) is recruited to replication forks blocked by DNA interstrand crosslinks (ICL-DNA) through interaction with the RPA complex and the Fanconi anemia (FA) core complex. The RPA heterotrimer associates both with single strand DNA (ssDNA) that is produced by DNA resection at ICL-DNA-stalled replication forks and with the FANCM and FAAP24 components of the FA core complex (Huang et al. 2010). ATRIP directly interacts with the FANCL component of the FA core complex (Tomida et al. 2013). The presence of RAD17 and TOPB1, which is required for ATR activation at DNA double strand breaks (DSBs), is not needed for ATR activation at ICL-DNA (Tomida et al. 2013).

Literature References
PubMed ID Title Journal Year
23723247 A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair

Tomida, J, Itaya, A, Shigechi, T, Unno, J, Uchida, E, Ikura, M, Masuda, Y, Matsuda, S, Adachi, J, Kobayashi, M, Meetei, AR, Maehara, Y, Yamamoto, K, Kamiya, K, Matsuura, A, Matsuda, T, Ikura, T, Ishiai, M, Takata, M

Nucleic Acids Res. 2013
20670894 The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response

Huang, M, Kim, JM, Shiotani, B, Yang, K, Zou, L, D'Andrea, AD

Mol. Cell 2010
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