STAT1,STAT3,STAT6 phosphorylation

Stable Identifier
R-HSA-6788582
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once bound to the Interleukin-13 (IL13) type II receptor, Signal transducer and activator of transcription 3 (STAT3) is tyrosine phosphorylated by Janus kinase 2 (JAK2), while STAT1 and STAT6 are phosphorylated by Non-receptor tyrosine kinase 2 (TYK2) (Bhattacharjee et al. 2013).

Literature References
PubMed ID Title Journal Year
23124025 IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

Bhattacharjee, A, Shukla, M, Yakubenko, VP, Mulya, A, Kundu, S, Cathcart, MK

Free Radic. Biol. Med. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine kinase activity of IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed