ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins

Stable Identifier
R-HSA-6788650
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Protein-S-isoprenylcysteine O-methyltransferase (ICMT) mediates the post-translational methyl esterification of C-terminal CAAX motifs in prenylated proteins such as the oncoprotein RAS and related GTPases, neutralising the negative charge of prenylcysteine species and thereby determining their subcellular localisation and correct biological function (Wright et al. 2009, Yang et al. 2011). ICMT may serve as a therapeutic target in cancer development (Lau et al. 2014, Diver et al. 2014).

Literature References
PubMed ID Title Journal Year
24971579 An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo

Lau, HY, Ramanujulu, PM, Guo, D, Yang, T, Wirawan, M, Casey, PJ, Go, ML, Wang, M

Cancer Biol. Ther. 2014
22195972 Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT

Yang, J, Kulkarni, K, Manolaridis, I, Zhang, Z, Dodd, RB, Mas-Droux, C, Barford, D

Mol. Cell 2011
19158273 Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe

Wright, LP, Court, H, Mor, A, Ahearn, IM, Casey, PJ, Philips, MR

Mol. Cell. Biol. 2009
25059662 Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites

Diver, MM, Long, SB

J. Biol. Chem. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity of ICMT:Zn2+ [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created