Protein-S-isoprenylcysteine O-methyltransferase (ICMT) mediates the post-translational methyl esterification of C-terminal CAAX motifs in prenylated proteins such as the oncoprotein RAS and related GTPases, neutralising the negative charge of prenylcysteine species and thereby determining their subcellular localisation and correct biological function (Wright et al. 2009, Yang et al. 2011). ICMT may serve as a therapeutic target in cancer development (Lau et al. 2014, Diver et al. 2014).
Zhang, Z, Yang, J, Kulkarni, K, Mas-Droux, C, Manolaridis, I, Barford, D, Dodd, RB
Guo, D, Yang, T, Wirawan, M, Casey, PJ, Lau, HY, Wang, M, Go, ML, Ramanujulu, PM
Court, H, Casey, PJ, Philips, MR, Wright, LP, Ahearn, IM, Mor, A
Long, SB, Diver, MM
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity of ICMT:Zn2+ [endoplasmic reticulum membrane]
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