AK4 phosphorylates (d)NMPs to (d)NDPs

Stable Identifier
R-HSA-6788798
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyze the phosphorylation of AMP by using ATP or GTP as phosphate donors. AKs are thus involved in maintaining the homeostasis of cellular nucleotides. CMP, dCMP and dAMP are other substrates phosphorylated with less efficiency by AKs. When GTP is the phosphate donor, only AMP and CMP are efficiently phosphorylated. Adenylate kinase 4 (AK4) can mediate nucleotide homeostasis in the mitochondrion (Panayiotou et al. 2010).

Literature References
PubMed ID Title Journal Year
19766732 Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4

Panayiotou, C, Solaroli, N, Johansson, M, Karlsson, A

Int. J. Biochem. Cell Biol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside monophosphate kinase activity of AK4 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created