AK6 phosphorylates (d)NMPs to (d)NDPs

Stable Identifier
R-HSA-6788810
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyze the phosphorylation of AMP by using ATP or GTP as phosphate donors. AKs are thus involved in maintaining the homeostasis of cellular nucleotides. CMP, dCMP and dAMP are other substrates phosphorylated with less efficiency by AKs. When GTP is the phosphate donor, only AMP and CMP are efficiently phosphorylated. Adenylate kinase 6 (AK6) is thought to mediate nucleotide homeostasis in the nucleoplasm (Ren et al. 2005).

Literature References
PubMed ID Title Journal Year
15630091 The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus

Ren, H, Wang, L, Bennett, M, Liang, Y, Zheng, X, Lu, F, Li, L, Nan, J, Luo, M, Eriksson, S, Zhang, C, Su, XD

Proc. Natl. Acad. Sci. U.S.A. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside monophosphate kinase activity of AK6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created