Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins

Stable Identifier
R-HSA-6789218
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle lumen
ReviewStatus
5/5
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Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins
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HOCl reacts with the double bonds of unsaturated lipids and cholesterol to give chlorohydrins (RCH(Cl)-CH(OH)R'). Chlorohydrins, if formed in cell membranes, could cause disruption to membrane structure, since they are more polar than the parent fatty acids (Winterbourn CC et al. 1992; van den Berg JJ et al 1993).
Literature References
PubMed ID Title Journal Year
8263423 Hypochlorous acid-mediated modification of cholesterol and phospholipid: analysis of reaction products by gas chromatography-mass spectrometry

Winterbourn, CC, van den Berg, JJ, Kuypers, FA

J. Lipid Res. 1993
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Authored
Shamovsky, V  (2018-10-23)
Reviewed
Nüsse, O  (2018-11-07)
Created
Shamovsky, V  (2015-07-29)
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