LIPs hydrolyse TG to DAG and RCOOH

Stable Identifier
R-HSA-6789310
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Lipases are enzymes that hydrolyse dietary lipids such as fats, oils and triglycerides. The majority of human lipases are secreted by the pancreas and function mainly in the digestive system. Lipase members K, M and N (LIPK, M and N), however, all appear to play a role in the last step of keratinocyte differentiation where they are proposed to hydrolyse triglycerides to free fatty acids and glycerol which is essential to stratum corneum hydration (Toulza et al. 2007).

Literature References
PubMed ID Title Journal Year
17562024 Large-scale identification of human genes implicated in epidermal barrier function

Toulza, E, Mattiuzzo, NR, Galliano, MF, Jonca, N, Dossat, C, Jacob, D, de Daruvar, A, Wincker, P, Serre, G, Guerrin, M

Genome Biol. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lipoprotein lipase activity of keratinocyte LIPs [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed