Reactome | FSCN1 [cytosol]

FSCN1 [cytosol]

Stable Identifier

R-HSA-6789835

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Fascin, FSCN1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16658 FSCN1

Gene Names

FSCN1, FAN1, HSN, SNL

Chain

initiator methionine:, chain:2-493

Reference Genes

BioGPS Gene:6624 FSCN1

COSMIC (genes):FAN1 FSCN1

COSMIC (genes):FSCN1 FSCN1

CTD Gene:6624 FSCN1

dbSNP Gene:6624 FSCN1

ENSEMBL:ENSG00000075618 FSCN1

HGNC:11148 FSCN1

KEGG:hsa:6624 FSCN1

Monarch:6624 FSCN1

NCBI Gene:6624 FSCN1

OMIM:602689 FSCN1

UCSC:Q16658 FSCN1

Reference Transcript

RefSeq:NM_003088.3 FSCN1

Other Identifiers

11715491_s_at

11747355_a_at

11747356_x_at

17043294

201564_PM_s_at

201564_s_at

210933_PM_s_at

210933_s_at

2988727

2988728

2988729

2988730

2988731

2988736

2988737

2988738

2988739

2988740

2988741

2988742

2988743

2988744

2988745

2988746

2988747

2988748

3588193

3588196

3588197

3588199

3588200

3588206

3588208

39070_at

6624

8131339

A_23_P168531

A_23_P168532

A_33_P3411075

GE58859

GO:0001725

GO:0001726

GO:0002102

GO:0003723

GO:0003779

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005902

GO:0005911

GO:0005938

GO:0007010

GO:0007015

GO:0007043

GO:0007163

GO:0008092

GO:0010592

GO:0015629

GO:0016477

GO:0030027

GO:0030035

GO:0030036

GO:0030046

GO:0030175

GO:0030426

GO:0030674

GO:0031253

GO:0032534

GO:0032956

GO:0034330

GO:0035089

GO:0042995

GO:0043226

GO:0044393

GO:0045296

GO:0048870

GO:0051015

GO:0051017

GO:0051491

GO:0060090

GO:0070062

GO:0070161

GO:0071803

GO:0090091

HMNXSV003056688

ILMN_1808707

PH_hs_0031568

TC07000055.hg

U03057_at

g13436196_3p_s_at

g4507114_3p_s_at

Participates

as a member of

STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000075618

ENSEMBL

ENST00000382361, ENSP00000371798, ENSG00000075618

HPA

ENSG00000075618-FSCN1

GeneCards

FSCN1

PRO

Q16658

Pharos - Targets

Q16658

GlyGen

Q16658

PDB

1DFC, 6I16, 6B0T, 6I17, 6I0Z, 6I13, 6I12, 3LLP, 6I18, 6I10, 4GOV, 4GP0, 3P53, 6I11, 6I14, 6I15, 7ZAU, 4GOY, 4GP3

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481)	0.649	6
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.597	7
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	3
UniProt:Q9NVI1 FANCI	3	FANCI [nucleoplasm] (R-HSA-419529) MonoUb-K523,p-4S-FANCI [nucleoplasm] (R-HSA-6785321) p-4S-FANCI [nucleoplasm] (R-HSA-6788480)	0.532	3
UniProt:P54278 PMS2	3	PMS2 [nucleoplasm] (R-HSA-5357527) PMS2 R628* [nucleoplasm] (R-HSA-5632980) PMS2 R134* [nucleoplasm] (R-HSA-5632982)	0.532	6
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	12

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