Expression of PTGS2

Stable Identifier
R-HSA-6790029
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014), including the gene which encodes the endoplasmic reticulum membrane protein Prostaglandin G/H synthase 2 (PTGS2, COX2) (Lo et al. 2010).

Literature References
PubMed ID Title Journal Year
24743777 STAT3 Target Genes Relevant to Human Cancers

Carpenter, RL, Lo, HW

Cancers (Basel) 2014
20145033 Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes

Lo, HW, Cao, X, Zhu, H, Ali-Osman, F

Mol. Cancer Res. 2010
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created