HVEM induses BTLA phosphorylation

Stable Identifier
R-HSA-6790087
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Binding of HVEM to BTLA induces tyrosine phosphorylation of BTLA on three cytoplasmic tyrosines. The phosphorylated tyrosine Y274 and 299 ( Y257 and 282 in human BTLA) associate with tyrosine phosphatase SHP2 and down regulate proximal TCR signalling. Phosphorylated Y245 (Y226 in human BTLA) in BTLA associates with growth receptor bound 2 (GRB2) (Murphy et al. 2006).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of unknown kinase [cytosol]
Physical Entity
Activity
Inferred From
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Reviewed
Created