SUMOylation of XPC

Stable Identifier
R-HSA-6790454
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

XPC undergoes SUMOylation following UV irradiation on several consensus SUMOylation sites (van Cuijk et al. 2015). SUMOylation of XPC probably succeeds the UV-DDB mediated ubiquitination of XPC, as the presence of both DDB2 and XPA is required for SUMOylation (Wang et al. 2005), but it has also been reported that SUMOylation of XPC was DDB2-independent (Akita et al. 2015). It is unclear whether XPC is modified by SUMO1 (Wang et al. 2005, Akita et al. 2015) or poly-SUMO2/3 (Poulsen et al. 2013). SUMO conjugases PIAS1 and PIAS3 both interact with XPC and may catalyze XPC SUMOylation (Akita et al. 2015).

Literature References
PubMed ID Title Journal Year
16030353 DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation

Wang, QE, Zhu, Q, Wani, G, El-Mahdy, MA, Li, J, Wani, AA

Nucleic Acids Res. 2005
26042670 SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair

Akita, M, Tak, YS, Shimura, T, Matsumoto, S, Okuda-Shimizu, Y, Shimizu, Y, Nishi, R, Saitoh, H, Iwai, S, Mori, T, Ikura, T, Sakai, W, Hanaoka, F, Sugasawa, K

Sci Rep 2015
26151477 SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

van Cuijk, L, van Belle, GJ, Turkyilmaz, Y, Poulsen, SL, Janssens, RC, Theil, AF, Sabatella, M, Lans, H, Mailand, N, Houtsmuller, AB, Vermeulen, W, Marteijn, JA

Nat Commun 2015
23751493 RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

Poulsen, SL, Hansen, RK, Wagner, SA, van Cuijk, L, van Belle, GJ, Streicher, W, Wikström, M, Choudhary, C, Houtsmuller, AB, Marteijn, JA, Bekker-Jensen, S, Mailand, N

J. Cell Biol. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created