RNF111 ubiquitinates SUMOylated XPC

Stable Identifier
R-HSA-6790487
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SUMOylated XPC is recognized by the SUMO-targeted ubiquitin ligase RNF111 (Arcadia) that, together with the E2 ubiquitin conjugating complex of UBE2N (UBC13) and UBE2V2 (MMS2), generates K63-linked polyubiquitin chains on XPC (Poulsen et al. 2013) to efficiently release XPC from UV lesions (van Cuijk et al. 2015). The release of K63-polyubiquitinated XPC occurs from GG-NER pre-incision complexes that contain TFIIH and XPA and promotes optimal access/binding of ERCC5 (XPG) endonuclease to the pre-incision complex (van Cuijk et al. 2015). Successful binding of ERCC5 endonuclease 3' to the damage facilitates binding of the ERCC1:ERCC4 (ERCC1:XPF) endonuclease and progression of the NER reaction.

Literature References
PubMed ID Title Journal Year
23751493 RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

Poulsen, SL, Hansen, RK, Wagner, SA, van Cuijk, L, van Belle, GJ, Streicher, W, Wikström, M, Choudhary, C, Houtsmuller, AB, Marteijn, JA, Bekker-Jensen, S, Mailand, N

J. Cell Biol. 2013
26151477 SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

van Cuijk, L, van Belle, GJ, Turkyilmaz, Y, Poulsen, SL, Janssens, RC, Theil, AF, Sabatella, M, Lans, H, Mailand, N, Houtsmuller, AB, Vermeulen, W, Marteijn, JA

Nat Commun 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RNF111 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created