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FCF1 [nucleoplasm]
Stable Identifier
R-HSA-6790672
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
rRNA-processing protein FCF1 homolog, FCF1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P31944 CASP14
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
FCF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y324 FCF1
Gene Names
FCF1, C14orf111, CGI-35
Chain
chain:1-198
Reference Genes
BioGPS Gene:51077 FCF1
COSMIC (genes):FCF1 FCF1
CTD Gene:51077 FCF1
dbSNP Gene:51077 FCF1
ENSEMBL:ENSG00000119616 FCF1
HGNC:20220 FCF1
Monarch:51077 FCF1
NCBI Gene:51077 FCF1
UCSC:Q9Y324 FCF1
Reference Transcript
RefSeq:NM_015962.4 FCF1
Other Identifiers
11739430_x_at
11739431_x_at
11753299_a_at
11753300_x_at
11762067_at
11762068_x_at
16786475
212499_PM_s_at
212499_s_at
219927_PM_at
219927_at
240928_PM_at
240928_at
2769896
3544217
3544218
3544220
3544221
3544224
3544225
3544227
3544229
3544230
3544231
3544233
3544234
3544235
3544236
3544237
3544238
3544239
3544240
3544242
3544244
51077
78285_i_at
78288_f_at
7975713
84019_at
A_14_P107088
A_24_P56407
A_32_P202092
A_33_P3264505
GE58630
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0006364
GO:0032040
GO:0042254
GO:0042274
GO:0043226
HMNXSV003001537
HMNXSV003026824
Hs.162102.0.A1_3p_at
ILMN_2189869
ILMN_2189870
PH_hs_0016622
TC14000462.hg
g7705729_3p_s_at
Participates
as a component of
SSU Processome [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA
(Homo sapiens)
Inferred To
Bka [nucleoplasm]
(Drosophila melanogaster)
Fcf1 [nucleoplasm]
(Mus musculus)
Fcf1 [nucleoplasm]
(Rattus norvegicus)
FCF1 [nucleoplasm]
(Bos taurus)
FCF1 [nucleoplasm]
(Caenorhabditis elegans)
FCF1 [nucleoplasm]
(Canis familiaris)
FCF1 [nucleoplasm]
(Gallus gallus)
FCF1 [nucleoplasm]
(Plasmodium falciparum)
FCF1 [nucleoplasm]
(Saccharomyces cerevisiae)
FCF1 [nucleoplasm]
(Sus scrofa)
fcf1 [nucleoplasm]
(Dictyostelium discoideum)
fcf1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
ENSEMBL
ENST00000341162
,
ENSP00000344393
OpenTargets
ENSG00000119616
HPA
ENSG00000119616-FCF1
PRO
Q9Y324
Pharos - Targets
Q9Y324
PDB
7MQA
,
7MQ9
,
7MQ8
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P287 BCCIP
0.556
3
UniProt:Q5MJ68 SPDYC
0.556
3
UniProt:P47929 LGALS7
1
LGALS7 [cytosol]
(R-HSA-9861116)
0.527
2
UniProt:P42357 HAL
1
HAL [cytosol]
(R-HSA-70897)
0.527
2
UniProt:P36952 SPB5
0.527
2
UniProt:P58107 EPIPL
0.527
2
UniProt:Q5T749 KPRP
1
KPRP [cytosol]
(R-HSA-9839614)
0.527
2
UniProt:P31944 CASP14
2
CASP14(6-146) [cytosol]
(R-HSA-8847667)
CASP14(153-242) [cytosol]
(R-HSA-8847687)
0.527
2
UniProt:Q6ZVX7 FBX50
0.527
2
UniProt:P02511 CRYAB
1
CRYAB [nucleoplasm]
(R-HSA-6806336)
0.527
2
UniProt:Q8IW75 SPA12
0.527
2
UniProt:Q9Y446 PKP3
2
PKP3 [cornified envelope]
(R-HSA-8847728)
PKP3 [plasma membrane]
(R-HSA-6814399)
0.527
2
UniProt:P50452 SERPINB8
1
SERPINB8 [plasma membrane]
(R-HSA-2990856)
0.527
2
UniProt:Q6UWP8 SBSN
1
SBSN [secretory granule lumen]
(R-HSA-9839544)
0.527
2
UniProt:Q8NEX9 SDR9C7
1
SDR9C7 [endoplasmic reticulum membrane]
(R-HSA-4084690)
0.527
2
UniProt:Q9NZT1 CALML5
3
CALML5 [cytosol]
(R-HSA-9839523)
CALML5 [extracellular region]
(R-HSA-6806470)
CALML5 [ficolin-1-rich granule lumen]
(R-HSA-6801291)
0.527
2
UniProt:P61020 RAB5B
8
GGC-RAB5B [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871126)
RAB5B [early endosome membrane]
(R-HSA-2029080)
GGC-RAB5B [early endosome membrane]
(R-HSA-8875327)
GGC-RAB5B [cytosol]
(R-HSA-8870434)
RAB5B [cytosol]
(R-HSA-8870412)
GGC-RAB5B [macropinosome membrane]
(R-HSA-9837696)
RAB5B [plasma membrane]
(R-HSA-6804984)
RAB5B [secretory granule membrane]
(R-HSA-6804966)
0.527
2
UniProt:Q53RT3 APRV1
0.527
2
UniProt:O43240 KLK10
0.527
2
UniProt:P20930 FLG
2
FLG(?-?) [cytosol]
(R-HSA-6810859)
FLG(1-4061) [cytosol]
(R-HSA-8849818)
0.527
2
UniProt:P17931 LGALS3
3
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
LGALS3 [plasma membrane]
(R-HSA-879445)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
0.527
2
UniProt:P48163 ME1
2
p-S336-ME1 [cytosol]
(R-HSA-9861606)
ME1 [cytosol]
(R-HSA-400119)
0.527
2
UniProt:P05120 SERPINB2
2
SERPINB2 [plasma membrane]
(R-HSA-159004)
SERPINB2 [extracellular region]
(R-HSA-158997)
0.527
2
UniProt:O60437 PPL
2
PPL [cytosol]
(R-HSA-6810850)
PPL [cornified envelope]
(R-HSA-8847709)
0.527
2
UniProt:Q92817 EVPL
2
EVPL [cornified envelope]
(R-HSA-8847741)
EVPL [cytosol]
(R-HSA-6810853)
0.527
2
UniProt:P07476 IVL
2
IVL [cornified envelope]
(R-HSA-8847720)
IVL [cytosol]
(R-HSA-6810837)
0.527
2
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