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NOP56 [nucleoplasm]
Stable Identifier
R-HSA-6790696
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleolar protein 56, NOP56_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
18SE pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
47S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides (Homo sapiens)
Box C/D snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP56 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00567 NOP56
Gene Names
NOP56, NOL5A
Chain
chain:1-594
Reference Genes
BioGPS Gene:10528 NOP56
COSMIC (genes):NOP56 NOP56
CTD Gene:10528 NOP56
dbSNP Gene:10528 NOP56
ENSEMBL:ENSG00000101361 NOP56
HGNC:15911 NOP56
Monarch:10528 NOP56
NCBI Gene:10528 NOP56
OMIM:614154 NOP56
UCSC:O00567 NOP56
Reference Transcript
RefSeq:NM_006392.3 NOP56
Other Identifiers
10528
11746134_s_at
11746135_x_at
11755342_x_at
11758679_s_at
16910825
17119258
17119260
17119262
17119264
17125850
200874_PM_s_at
200874_s_at
200875_PM_s_at
200875_s_at
2947503
2947504
2947506
2947507
34882_at
3873877
3873878
3873879
3873880
3873882
3873883
3873884
3873885
3873886
3873887
3873888
3873889
3873890
3873891
3873892
3873893
3873894
3873895
3873896
3873897
3873898
3873899
3873900
3873901
3873902
3873903
3873904
3873905
3873906
3873907
3873908
3873909
3873910
3873911
3873912
3873913
3873914
3873915
3873917
8060484
8060501
8060503
A_14_P125369
A_14_P133992
A_21_P0000282
A_21_P0000335
A_21_P0000394
A_21_P0000500
A_23_P79927
A_23_P91328
GE60295
GO:0001650
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005732
GO:0005737
GO:0006364
GO:0016020
GO:0030515
GO:0031428
GO:0032040
GO:0042254
GO:0042274
GO:0043226
GO:0045296
GO:0070761
GO:1990226
GO:1990904
HMNXSV003011684
HMNXSV003014481
HMNXSV003017034
HMNXSV003021207
HMNXSV003025930
HMNXSV003029144
HMNXSV003052560
Hs.296585.0.S1_3p_s_at
ILMN_1705407
ILMN_1787628
ILMN_2044832
ILMN_2209515
PH_hs_0018286
RNA33507|snoRNA_scaRNA_103_132
RNA33604|snoRNA_scaRNA_200_86
RNA33695|snoRNA_scaRNA_291_75
RNA33723|snoRNA_scaRNA_319_72
RNA33727|snoRNA_scaRNA_323_71
TC20001062.hg
g5453793_3p_a_at
p10514
p10515
Participates
as a component of
Box C/D snoRNP [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
Other forms of this molecule
NOP56 [cytosol]
Inferred To
nol-56 [nucleoplasm]
(Caenorhabditis elegans)
NOP56 [nucleoplasm]
(Bos taurus)
NOP56 [nucleoplasm]
(Canis familiaris)
NOP56 [nucleoplasm]
(Gallus gallus)
NOP56 [nucleoplasm]
(Plasmodium falciparum)
NOP56 [nucleoplasm]
(Saccharomyces cerevisiae)
NOP56 [nucleoplasm]
(Sus scrofa)
nop56 [nucleoplasm]
(Dictyostelium discoideum)
nop56 [nucleoplasm]
(Schizosaccharomyces pombe)
Nop56 [nucleoplasm]
(Drosophila melanogaster)
Nop56 [nucleoplasm]
(Mus musculus)
Nop56 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000329276
,
ENSP00000370589
OpenTargets
ENSG00000101361
HPA
ENSG00000101361-NOP56
PRO
O00567
Pharos - Targets
O00567
GlyGen
O00567
Orphanet
NOP56
PDB
7MQ9
,
7MQ8
,
7MQA
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y2X3 NOP58
3
polySUMO2-K467,K497-NOP58 [nucleoplasm]
(R-HSA-4570460)
monoSUMO1-K467,K497-NOP58 [nucleoplasm]
(R-HSA-4570470)
NOP58 [nucleoplasm]
(R-HSA-4570488)
0.643
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.564
2
UniProt:Q9Y4Z2 NEUROG3
1
NEUROG3 [nucleoplasm]
(R-HSA-189530)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.527
3
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.527
2
UniProt:P15880 RPS2
3
RPS2 [cytosol]
(R-HSA-72347)
Me2aR-RPS2 [cytosol]
(R-HSA-8879138)
RPS2 [nucleoplasm]
(R-HSA-6790655)
0.527
2
UniProt:P62753 RPS6
4
RPS6 [cytosol]
(R-HSA-72381)
p-5S-RPS6 [cytosol]
(R-HSA-165727)
3OHR147-RPS6 [cytosol]
(R-HSA-9629876)
RPS6 [nucleoplasm]
(R-HSA-6790606)
0.483
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
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