Reactome | GAR1 [nucleoplasm]

GAR1 [nucleoplasm]

Stable Identifier

R-HSA-6790707

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

H/ACA ribonucleoprotein complex subunit 1, GAR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NY12 GAR1

Gene Names

GAR1, NOLA1

Chain

chain:1-217

Reference Genes

BioGPS Gene:54433 GAR1

COSMIC (genes):GAR1 GAR1

CTD Gene:54433 GAR1

dbSNP Gene:54433 GAR1

ENSEMBL:ENSG00000109534 GAR1

HGNC:14264 GAR1

KEGG:hsa:54433 GAR1

Monarch:54433 GAR1

NCBI Gene:54433 GAR1

OMIM:606468 GAR1

UCSC:Q9NY12 GAR1

Reference Transcript

Participates

as a component of

as an input of

Biogenesis and assembly of the telomerase RNP (Homo sapiens)

Inferred To

Gar1 [nucleoplasm] (Drosophila melanogaster)

Gar1 [nucleoplasm] (Mus musculus)

Gar1 [nucleoplasm] (Rattus norvegicus)

garr-1 [nucleoplasm] (Caenorhabditis elegans)

gar1 [nucleoplasm] (Dictyostelium discoideum)

gar1 [nucleoplasm] (Schizosaccharomyces pombe)

GAR1 [nucleoplasm] (Bos taurus)

GAR1 [nucleoplasm] (Gallus gallus)

GAR1 [nucleoplasm] (Plasmodium falciparum)

GAR1 [nucleoplasm] (Saccharomyces cerevisiae)

GAR1 [nucleoplasm] (Sus scrofa)

Ghost homologue of GAR1 [nucleoplasm] (Canis familiaris)

Cross References

RefSeq

NP_061856.1, NP_127460.1

ENSEMBL

ENSG00000109534, ENSP00000378127, ENST00000226796, ENSP00000226796, ENST00000394631

OpenTargets

ENSG00000109534

GeneCards

GAR1

HPA

ENSG00000109534-GAR1

PRO

Q9NY12

Pharos - Targets

Q9NY12

GlyGen

Q9NY12

PDB

7V9A, 8OUF, 7BGB, 7TRC, 8OUE

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.793	6
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.643	4
UniProt:Q9NPE3 NOP10	1	NOP10 [nucleoplasm] (R-HSA-6790665)	0.643	5
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.544	2
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.527	3
UniProt:Q9BQA1 WDR77	3	WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610)	0.527	2
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.527	3
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.527	3
UniProt:Q9Y4F1 FARP1	1	FARP1 [cytosol] (R-HSA-9679578)	0.527	2
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	3

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