WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639

Stable Identifier
R-HSA-6790982
Type
Reaction [transition]
Species
Homo sapiens
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The WBSCR22:TRMT112 complex, homolog of the Bud23:Trm112 complex in yeast (Ounap et al. 2013), methylates guanosine-1639 of 18S rRNA at the N(7) position of the guanine base (Haag et al. 2015, Zorbas et al. 2015). The WBSCR22:TRMT112 complex but not its methylase activity is required for efficient processing of precursor rRNA at site 2 and site 3 (Haag et al. 2015, Zorbas et al. 2015). Hemizygosity at the region containing WBSCR22 causes Williams-Beuren syndrome (Doll and Grzeschik 2001).

Literature References
PubMed ID Title Journal Year
24086612 The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells

Õunap, K, Käsper, L, Kurg, A, Kurg, R

PLoS ONE 2013
25851604 The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis

Zorbas, C, Nicolas, E, Wacheul, L, Huvelle, E, Heurgué-Hamard, V, Lafontaine, DL

Mol. Biol. Cell 2015
25525153 WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA

Haag, S, Kretschmer, J, Bohnsack, MT

RNA 2015
11978965 Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome

Doll, A, Grzeschik, KH

Cytogenet. Cell Genet. 2001
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Title
rRNA (guanine-N7-)-methyltransferase activity of WBSCR22:TRIMT112 [nucleoplasm]
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