GADD45A binds PCNA

Stable Identifier
R-HSA-6791109
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GADD45A binds PCNA homotrimer (Smith et al. 1994, Hall et al. 1995, Sanchez et al. 2010). The consequences of this interaction are not clear. Binding to GADD45A may negatively regulate PCNA-mediated DNA synthesis during S phase of the cell cycle or it may promote PCNA-mediated DNA repair synthesis (Smith et al. 1994, Kim et al. 2013).

Literature References
PubMed ID Title Journal Year
23485469 A novel role for Gadd45? in base excision repair: modulation of APE1 activity by the direct interaction of Gadd45? with PCNA

Kim, HL, Kim, SU, Seo, YR

Biochem. Biophys. Res. Commun. 2013
20460379 Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Sánchez, R, Pantoja-Uceda, D, Prieto, J, Diercks, T, Marcaida, MJ, Montoya, G, Campos-Olivas, R, Blanco, FJ

J. Biol. Chem. 2010
7973727 Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

Smith, ML, Chen, IT, Zhan, Q, Bae, I, Chen, CY, Gilmer, TM, Kastan, MB, O'Connor, PM, Fornace, AJ

Science 1994
7784094 Characterisation of the interaction between PCNA and Gadd45

Hall, PA, Kearsey, JM, Coates, PJ, Norman, DG, Warbrick, E, Cox, LS

Oncogene 1995
Participants
Participant Of
Orthologous Events
Authored
Reviewed