Reactome | RPS16 [nucleoplasm]

RPS16 [nucleoplasm]

Stable Identifier

R-HSA-6791196

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S ribosomal protein S16, RS16_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P27635 RPL10

Expand all

External Reference Information

External Reference

UniProt:P62249 RPS16

Gene Names

RPS16

Chain

initiator methionine:, chain:2-146

Reference Genes

BioGPS Gene:6217 RPS16

COSMIC (genes):RPS16 RPS16

CTD Gene:6217 RPS16

dbSNP Gene:6217 RPS16

ENSEMBL:ENSG00000105193 RPS16

HGNC:10396 RPS16

KEGG:hsa:6217 RPS16

Monarch:6217 RPS16

NCBI Gene:6217 RPS16

OMIM:603675 RPS16

UCSC:P62249 RPS16

Reference Transcript

RefSeq:NM_001020.5 RPS16

Other Identifiers

11758289_x_at

11763033_at

16872229

201258_PM_at

201258_at

213890_PM_x_at

213890_x_at

226130_PM_at

226130_at

226131_PM_s_at

226131_s_at

38061_at

3862019

3862020

3862021

3862022

3862023

3862024

3862025

3862026

3862027

3862028

3862029

3862030

3862031

3862032

6217

8036737

87783_at

A_23_P208850

GE80063

GE85336

GE88165

GO:0000462

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006364

GO:0006412

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0032040

GO:0042274

GO:0043226

GO:0045202

GO:0070062

GO:1990830

GO:1990904

HMNXSV003030940

Hs.80617.2.S1_3p_x_at

ILMN_1651850

ILMN_1713394

M60854_at

PH_hs_0037828

TC19001521.hg

g4506690_3p_a_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS16 [cytosol]

Inferred To

Homologues of RPS16 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of RPS16 [nucleoplasm] (Schizosaccharomyces pombe)

Rps16 [nucleoplasm] (Mus musculus)

Rps16 [nucleoplasm] (Rattus norvegicus)

rps16 [nucleoplasm] (Danio rerio)

rps16 [nucleoplasm] (Dictyostelium discoideum)

rps16 [nucleoplasm] (Xenopus tropicalis)

rps-16 [nucleoplasm] (Caenorhabditis elegans)

rps1601 [nucleoplasm] (Schizosaccharomyces pombe)

RPS16 [nucleoplasm] (Bos taurus)

RPS16 [nucleoplasm] (Canis familiaris)

RPS16 [nucleoplasm] (Gallus gallus)

RPS16 [nucleoplasm] (Plasmodium falciparum)

RPS16 [nucleoplasm] (Sus scrofa)

RPS16B [nucleoplasm] (Saccharomyces cerevisiae)

RPS16A [nucleoplasm] (Saccharomyces cerevisiae)

RpS16 [nucleoplasm] (Drosophila melanogaster)

rps1602 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001011.1

OpenTargets

ENSG00000105193

ENSEMBL

ENST00000251453, ENSP00000251453

HPA

ENSG00000105193-RPS16

PRO

P62249

Pharos - Targets

P62249

GlyGen

P62249

PDB

6XA1, 6ZM7, 6ZLW, 6IP8, 6ZON, 6QZP, 6ZME, 5T2C, 6Y2L, 6Y57, 8GLP, 5OA3, 7MQ8, 5AJ0, 7QP6, 6IP5, 6Y0G, 6ZVH, 6Z6N, 8IFD, 6ZMW, 5VYC, 7WTZ, 7WTX, 6OLE, 6OLF, 4UG0, 8G6J, 5LKS, 8G5Y, 8JDL, 7XNX, 6OLZ, 6ZMI, 6G4S, 8JDK, 8JDM, 6G51, 7WTT, 8G60, 6ZN5, 8PPL, 4V6X, 8T4S, 6ZOL, 8OZ0, 7WU0, 6FEC, 7A09, 6YBS, 6ZP4, 5FLX, 6ZXE, 6G5I, 6ZXD, 6G5H, 7TQL, 7MQ9, 6ZUO, 6ZXG, 6ZXF, 7QP7, 6IP6, 6Z6M, 6OM0, 6Z6L, 7XNY, 6OLG, 6ZV6, 7MQA, 5A2Q, 6ZOJ, 6ZMO, 6ZVJ, 7R4X, 6ZXH, 6OM7, 7K5I, 8G61, 8IFE, 8PPK, 8JDJ, 7WTV, 8Y0W, 6G18, 6ZMT, 8Y0X, 7WTU, 7WTW, 6G53, 6G4W, 6OLI

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.715	5
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.669	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.642	4
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	4
UniProt:O60739 EIF1B			0.564	2
UniProt:Q9NX58 LYAR			0.564	2
UniProt:O76021 RL1D1			0.527	2
UniProt:P61254 RPL26	1	RPL26 [cytosol] (R-HSA-72436)	0.527	2
UniProt:Q9BYJ9 YTHD1			0.527	2
UniProt:P62263 RPS14	2	RPS14 [cytosol] (R-HSA-72333) RPS14 [nucleoplasm] (R-HSA-6790669)	0.527	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	4
UniProt:Q8N9T8 KRI1			0.527	2
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:P62899 RPL31	1	RPL31 [cytosol] (R-HSA-72454)	0.527	3
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	3
UniProt:Q5SSJ5 HP1B3			0.527	2
UniProt:P46783 RPS10	2	RPS10 [cytosol] (R-HSA-72325) RPS10 [nucleoplasm] (R-HSA-6798733)	0.527	3
UniProt:Q13823 NOG2			0.527	2
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.527	3
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.527	4
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q8IZH2 XRN1	1	XRN1 [cytosol] (R-HSA-429835)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	2
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.527	2
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:Q96KR1 ZFR			0.527	2
UniProt:Q9BRT6 LLPH			0.527	2
UniProt:Q9Y3B2 EXOSC1	2	EXOSC1 [nucleoplasm] (R-HSA-6791578) EXOSC1 [cytosol] (R-HSA-429841)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.527	2
UniProt:P42766 RPL35	1	RPL35 [cytosol] (R-HSA-72460)	0.527	3
UniProt:Q9H6S0 YTDC2			0.527	2
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.527	2
UniProt:Q6P158 DHX57			0.527	2
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.527	2
UniProt:Q9H9Y2 RPF1			0.527	2
UniProt:Q14684 RRP1B			0.527	2
UniProt:P62847 RPS24	2	RPS24 [cytosol] (R-HSA-72355) RPS24 [nucleoplasm] (R-HSA-6791186)	0.527	2
UniProt:P27635 RPL10	1	RPL10 [cytosol] (R-HSA-72402)	0.527	2
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.527	3
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	4
UniProt:P62841 RPS15	2	RPS15 [cytosol] (R-HSA-72335) RPS15 [nucleoplasm] (R-HSA-6798706)	0.527	2
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.527	2
UniProt:Q7Z2T5 TRM1L			0.527	2
UniProt:Q6PCB5 RSBNL			0.527	2
UniProt:Q66K89 E4F1			0.527	2
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:P08865 RPSA	2	RPSA [cytosol] (R-HSA-72389) RPSA [nucleoplasm] (R-HSA-6798722)	0.527	2
UniProt:Q4G0J3 LARP7			0.527	3
UniProt:P78316 NOP14	1	NOP14 [nucleoplasm] (R-HSA-6790710)	0.527	3
UniProt:Q7RTS1 BHLHA15	1	BHLHA15 [nucleoplasm] (R-HSA-9922593)	0.527	2
UniProt:Q7L2Z9 CENPQ	2	CENPQ [nucleoplasm] (R-HSA-606327) CENPQ [cytosol] (R-HSA-375298)	0.527	2
UniProt:Q8NHQ9 DDX55			0.483	2
UniProt:O75821 EIF3G	1	EIF3G [cytosol] (R-HSA-72538)	0.483	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.462	2

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