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RPS8 [nucleoplasm]
Stable Identifier
R-HSA-6791203
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
40S ribosomal protein S8, RS8_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
18SE pre-40S particle [nucleoplasm] (Homo sapiens)
RPS8 [nucleoplasm] (Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
RPS8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62241 RPS8
Gene Names
RPS8, OK/SW-cl.83
Chain
initiator methionine:1, chain:2-208
Reference Genes
BioGPS Gene:6202 RPS8
COSMIC (genes):RPS8 RPS8
CTD Gene:6202 RPS8
dbSNP Gene:6202 RPS8
ENSEMBL:ENSG00000142937 RPS8
ENSEMBL:ENSG00000142937.12 RPS8
HGNC:10441 RPS8
KEGG Gene (Homo sapiens):6202 RPS8
Monarch:6202 RPS8
NCBI Gene:6202 RPS8
OMIM:600357 RPS8
Reference Transcript
RefSeq:NM_001012.1 RPS8
Other Identifiers
11715543_x_at
16663989
200858_PM_s_at
200858_s_at
2334165
2334166
2334170
2334174
2334175
2334176
2334179
2334180
2334184
2334189
2334190
2805737
2805739
2805742
31583_at
3203916
3203922
3582023
3613011
3613012
6202
74705_s_at
7901038
A_23_P46182
GO:0000462
GO:0002181
GO:0003723
GO:0003735
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005783
GO:0005829
GO:0005840
GO:0005925
GO:0006412
GO:0016020
GO:0022626
GO:0022627
GO:0032040
GO:0042254
GO:0042274
GO:0043226
GO:0070062
GO:1990904
HMNXSV003008668
PH_hs_0034351
X67247_rna1_at
g4506742_3p_s_at
Participates
as a component of
18SE pre-40S particle [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA
(Homo sapiens)
Other forms of this molecule
RPS8 [cytosol]
Inferred To
LOC100000836 [nucleoplasm]
(Danio rerio)
RPS8A [nucleoplasm]
(Saccharomyces cerevisiae)
Rps8 [nucleoplasm]
(Mus musculus)
Rps8 [nucleoplasm]
(Rattus norvegicus)
rps8 [nucleoplasm]
(Dictyostelium discoideum)
rps8 [nucleoplasm]
(Xenopus tropicalis)
RPS8 [nucleoplasm]
(Bos taurus)
RPS8 [nucleoplasm]
(Canis familiaris)
RPS8 [nucleoplasm]
(Gallus gallus)
RPS8 [nucleoplasm]
(Plasmodium falciparum)
RPS8 [nucleoplasm]
(Sus scrofa)
rps-8 [nucleoplasm]
(Caenorhabditis elegans)
RpS8 [nucleoplasm]
(Drosophila melanogaster)
Homologues of RPS8 [nucleoplasm]
(Saccharomyces cerevisiae)
RPS8B [nucleoplasm]
(Saccharomyces cerevisiae)
rps802 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001003.1
OpenTargets
ENSG00000142937
GeneCards
P62241
HPA
ENSG00000142937-RPS8
Ensembl
ENSG00000142937
,
ENST00000396651
,
ENSP00000379888
PRO
P62241
Pharos - Targets
P62241
PDB
7WTW
,
6OLF
,
6G5H
,
6OLG
,
7WTX
,
6ZLW
,
5LKS
,
6ZV6
,
6ZMO
,
6OLE
,
6G51
,
7QP6
,
6Z6L
,
6ZMI
,
5VYC
,
6ZXE
,
7WTS
,
6G18
,
6ZON
,
6YBW
,
6ZVJ
,
6OM0
,
6ZVH
,
7WTV
,
7MQA
,
6ZOJ
,
7R4X
,
5A2Q
,
7TQL
,
6Y2L
,
6ZMT
,
5FLX
,
6ZM7
,
6G5I
,
6Y0G
,
4V6X
,
6ZXH
,
7MQ9
,
6Z6N
,
7WU0
,
5T2C
,
7QP7
,
6ZP4
,
6G4W
,
7MQ8
,
6Z6M
,
7WTZ
,
6ZXG
,
6ZUO
,
6XA1
,
6G4S
,
6ZXF
,
6G53
,
5OA3
,
6Y57
,
6OLZ
,
7A09
,
6OM7
,
6IP8
,
6FEC
,
6ZOK
,
6ZXD
,
4UG0
,
6ZME
,
7WTT
,
6QZP
,
7K5I
,
6ZN5
,
6OLI
,
7QVP
,
5AJ0
,
7WTU
,
6IP5
,
6ZMW
,
6IP6
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.643
4
UniProt:Q92796 DLG3
2
DLG3 [plasma membrane]
(R-HSA-443609)
DLG3 [cytosol]
(R-HSA-6794232)
0.556
3
UniProt:Q15700 DLG2
2
DLG2 [plasma membrane]
(R-HSA-9610662)
DLG2 [cytosol]
(R-HSA-6794230)
0.556
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
2
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.495
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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