Reactome | RPS8 [nucleoplasm]

RPS8 [nucleoplasm]

Stable Identifier

R-HSA-6791203

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S ribosomal protein S8, RS8_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P62241 RPS8

Gene Names

RPS8, OK/SW-cl.83

Chain

initiator methionine:1, chain:2-208

Reference Genes

BioGPS Gene:6202 RPS8

COSMIC (genes):RPS8 RPS8

CTD Gene:6202 RPS8

dbSNP Gene:6202 RPS8

ENSEMBL:ENSG00000142937 RPS8

ENSEMBL:ENSG00000142937.12 RPS8

HGNC:10441 RPS8

KEGG Gene (Homo sapiens):6202 RPS8

Monarch:6202 RPS8

NCBI Gene:6202 RPS8

OMIM:600357 RPS8

Reference Transcript

RefSeq:NM_001012.1 RPS8

Other Identifiers

11715543_x_at

16663989

200858_PM_s_at

200858_s_at

2334165

2334166

2334170

2334174

2334175

2334176

2334179

2334180

2334184

2334189

2334190

2805737

2805739

2805742

31583_at

3203916

3203922

3582023

3613011

3613012

6202

74705_s_at

7901038

A_23_P46182

GO:0000462

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0016020

GO:0022626

GO:0022627

GO:0032040

GO:0042254

GO:0042274

GO:0043226

GO:0070062

GO:1990904

HMNXSV003008668

PH_hs_0034351

X67247_rna1_at

g4506742_3p_s_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS8 [cytosol]

Inferred To

LOC100000836 [nucleoplasm] (Danio rerio)

RPS8A [nucleoplasm] (Saccharomyces cerevisiae)

Rps8 [nucleoplasm] (Mus musculus)

Rps8 [nucleoplasm] (Rattus norvegicus)

rps8 [nucleoplasm] (Dictyostelium discoideum)

rps8 [nucleoplasm] (Xenopus tropicalis)

RPS8 [nucleoplasm] (Bos taurus)

RPS8 [nucleoplasm] (Canis familiaris)

RPS8 [nucleoplasm] (Gallus gallus)

RPS8 [nucleoplasm] (Plasmodium falciparum)

RPS8 [nucleoplasm] (Sus scrofa)

rps-8 [nucleoplasm] (Caenorhabditis elegans)

RpS8 [nucleoplasm] (Drosophila melanogaster)

Homologues of RPS8 [nucleoplasm] (Saccharomyces cerevisiae)

RPS8B [nucleoplasm] (Saccharomyces cerevisiae)

rps802 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001003.1

OpenTargets

ENSG00000142937

GeneCards

P62241

HPA

ENSG00000142937-RPS8

Ensembl

ENSG00000142937, ENST00000396651, ENSP00000379888

PRO

P62241

Pharos - Targets

P62241

PDB

7WTW, 6OLF, 6G5H, 6OLG, 7WTX, 6ZLW, 5LKS, 6ZV6, 6ZMO, 6OLE, 6G51, 7QP6, 6Z6L, 6ZMI, 5VYC, 6ZXE, 7WTS, 6G18, 6ZON, 6YBW, 6ZVJ, 6OM0, 6ZVH, 7WTV, 7MQA, 6ZOJ, 7R4X, 5A2Q, 7TQL, 6Y2L, 6ZMT, 5FLX, 6ZM7, 6G5I, 6Y0G, 4V6X, 6ZXH, 7MQ9, 6Z6N, 7WU0, 5T2C, 7QP7, 6ZP4, 6G4W, 7MQ8, 6Z6M, 7WTZ, 6ZXG, 6ZUO, 6XA1, 6G4S, 6ZXF, 6G53, 5OA3, 6Y57, 6OLZ, 7A09, 6OM7, 6IP8, 6FEC, 6ZOK, 6ZXD, 4UG0, 6ZME, 7WTT, 6QZP, 7K5I, 6ZN5, 6OLI, 7QVP, 5AJ0, 7WTU, 6IP5, 6ZMW, 6IP6

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.643	4
UniProt:Q92796 DLG3	2	DLG3 [plasma membrane] (R-HSA-443609) DLG3 [cytosol] (R-HSA-6794232)	0.556	3
UniProt:Q15700 DLG2	2	DLG2 [plasma membrane] (R-HSA-9610662) DLG2 [cytosol] (R-HSA-6794230)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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