Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
BOP1 [nucleoplasm]
Stable Identifier
R-HSA-6791206
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
fullName evidence="2"Ribosome biogenesis protein BOP1, BOP1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)
32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm] (Homo sapiens)
PeBoW complex [nucleoplasm] (Homo sapiens)
BOP1 [nucleoplasm] (Homo sapiens)
PeBoW complex [nucleoplasm] (Homo sapiens)
BOP1 [nucleoplasm] (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
BOP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14137 BOP1
Gene Names
BOP1, KIAA0124
Chain
chain:1-746
Reference Genes
BioGPS Gene:23246 BOP1
COSMIC (genes):BOP1 BOP1
CTD Gene:23246 BOP1
dbSNP Gene:23246 BOP1
ENSEMBL:ENSG00000261236 BOP1
HGNC:15519 BOP1
Monarch:23246 BOP1
NCBI Gene:23246 BOP1
OMIM:610596 BOP1
UCSC:Q14137 BOP1
Reference Transcript
RefSeq:NM_015201.4 BOP1
Other Identifiers
11757102_a_at
17082507
212563_PM_at
212563_at
216397_PM_s_at
216397_s_at
23246
3158191
3158192
3158193
3158194
3158195
3158196
3158197
3158198
3158199
3158200
3158201
3158202
3158203
3158204
3158205
3158206
3158207
3158208
3158219
3158220
3158221
3158222
3158223
3158224
3158225
3158226
3158227
3158228
3158229
3158230
3158231
3158232
3158233
3158234
3158235
3158236
3158237
3158238
3158239
3158240
3158257
3158258
3158261
3158269
3158270
3158271
3158274
3158275
35615_at
8153664
8153678
A_23_P43800
D50914_at
GE57252
GO:0000027
GO:0000448
GO:0000460
GO:0000463
GO:0000466
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006364
GO:0008283
GO:0030687
GO:0042254
GO:0042273
GO:0043021
GO:0043226
GO:0051726
GO:0065003
GO:0070545
GO:1901796
GO:1990904
HMNXSV003026658
HMNXSV003051706
Hs.30736.0.S1_3p_at
Hs.30736.1.S1_3p_a_at
ILMN_1763955
PH_hs_0026681
TC08001743.hg
TC08001744.hg
Participates
as a component of
PeBoW complex [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA
(Homo sapiens)
Inferred To
erb1 [nucleoplasm]
(Schizosaccharomyces pombe)
BOP1 [nucleoplasm]
(Bos taurus)
BOP1 [nucleoplasm]
(Caenorhabditis elegans)
BOP1 [nucleoplasm]
(Canis familiaris)
BOP1 [nucleoplasm]
(Dictyostelium discoideum)
BOP1 [nucleoplasm]
(Drosophila melanogaster)
BOP1 [nucleoplasm]
(Gallus gallus)
BOP1 [nucleoplasm]
(Sus scrofa)
ERB1 [nucleoplasm]
(Saccharomyces cerevisiae)
bop1 [nucleoplasm]
(Danio rerio)
bop1 [nucleoplasm]
(Xenopus tropicalis)
Bop1 [nucleoplasm]
(Mus musculus)
Bop1 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000569669
,
ENSP00000455106
OpenTargets
ENSG00000261236
HPA
ENSG00000261236-BOP1
PRO
Q14137
Pharos - Targets
Q14137
GlyGen
Q14137
PDB
8FKT
,
8FKR
,
8FKS
,
8FKV
,
8FKX
,
8FKQ
,
8FKU
,
8FKW
,
8FKP
,
8FKY
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00541 PES1
1
PES1 [nucleoplasm]
(R-HSA-6791207)
0.758
6
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.706
4
UniProt:Q9GZL7 WDR12
1
WDR12 [nucleoplasm]
(R-HSA-6791215)
0.597
4
UniProt:Q8N0W7 FMR1N
0.527
2
UniProt:O75607 NPM3
0.527
3
UniProt:Q9H6Y2 WDR55
0.527
2
UniProt:O14958 CASQ2
1
CASQ2 [sarcoplasmic reticulum membrane]
(R-HSA-2855225)
0.527
2
UniProt:Q96HE9 PRR11
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.527
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text