Reactome | NCL [nucleoplasm]

NCL [nucleoplasm]

Stable Identifier

R-HSA-6791213

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nucleolin, NUCL_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P49407

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External Reference Information

External Reference

UniProt:P19338 NCL

Gene Names

NCL

Chain

initiator methionine:1, chain:2-710

Reference Genes

BioGPS Gene:4691 NCL

COSMIC (genes):NCL NCL

CTD Gene:4691 NCL

dbSNP Gene:4691 NCL

ENSEMBL:ENSG00000115053 NCL

HGNC:7667 NCL

KEGG Gene (Homo sapiens):4691 NCL

Monarch:4691 NCL

NCBI Gene:4691 NCL

OMIM:164035 NCL

UCSC:P19338 NCL

Reference Transcript

RefSeq:NM_005381.2 NCL

Other Identifiers

0002510110

11745154_a_at

11745155_s_at

16909491

200610_s_at

241892_at

2603459

2603461

2603462

2603463

2603465

2603466

2603467

2603468

2603471

2603473

2603474

2603477

2603479

2603481

2603483

2603485

2603486

2603487

2603488

2603489

2603490

2603491

2603492

2603493

2603495

2603496

2603498

32590_at

4691

8059689

A_23_P5551

GE81501

GO:0001525

GO:0003674

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005938

GO:0006397

GO:0006412

GO:0008022

GO:0008150

GO:0009058

GO:0016020

GO:0017148

GO:0019899

GO:0032991

GO:0034641

GO:0036464

GO:0042162

GO:0042802

GO:0043226

GO:0044547

GO:0045944

GO:0048026

GO:0048027

GO:0048646

GO:0048856

GO:0070062

GO:0071364

GO:1901838

GO:1990830

GO:1990904

Hs.253767.0.A1_3p_at

ILMN_1695422

ILMN_2121437

M60858_rna1_at

PH_hs_0004572

TC02002859.hg

g4885510_3p_a_at

This entity regulates

Positively

47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA

Inferred To

NCL [nucleoplasm] (Canis familiaris)

NCL [nucleoplasm] (Dictyostelium discoideum)

NCL [nucleoplasm] (Gallus gallus)

NCL [nucleoplasm] (Sus scrofa)

tra2 [nucleoplasm] (Drosophila melanogaster)

Ncl [nucleoplasm] (Mus musculus)

Ncl [nucleoplasm] (Rattus norvegicus)

rsp-8 [nucleoplasm] (Caenorhabditis elegans)

tra2b [nucleoplasm] (Danio rerio)

tra2b [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005372.2

OpenTargets

ENSG00000115053

HPA

ENSG00000115053-NCL

GeneCards

P19338

Ensembl

ENSP00000318195, ENSG00000115053, ENST00000322723

PRO

P19338

PDB

2FC9, 2FC8, 2KRR

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P39060-PRO_0000005794 COL18A1			0.784	12
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.71	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.643	4
ChEBI:28304 HEPARIN			0.623	2
UniProt:P11387 TOP1	2	SUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.59	3
UniProt:O95793 STAU1			0.577	3
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.558	2
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.558	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:Q9CR42 ANKR1			0.524	2
UniProt:Q14684-1 RRP1B			0.512	4
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3
IntAct:EBI-1549314 PROBE			0.499	2
IntAct:EBI-1549316 PROBE			0.499	2
UniProt:Q9Y6D6 BIG1			0.499	5
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.499	3
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:Q9UQ80 PA2G4	2	PA2G4 [azurophil granule lumen] (R-HSA-6799205) PA2G4 [extracellular region] (R-HSA-6806200)	0.499	2
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.463	2
UniProt:P27958-PRO_0000037577			0.463	4
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.463	3
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.463	2
UniProt:P35579 MYH9	1	MYH9 [cytosol] (R-HSA-419173)	0.463	3
UniProt:Q8N0X7 SPART			0.462	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
IntAct:EBI-5333170 SSRNA			0.462	3
IntAct:EBI-5333168 SSRNA			0.462	4
IntAct:EBI-5333262 SSDNA			0.462	4

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